نتایج جستجو برای: sulfonamides
تعداد نتایج: 2874 فیلتر نتایج به سال:
Fluorescence amplified detection of proteases by the catalytic activation of a semisynthetic sensor.
A general approach to mimic the sensing scheme of allosteric enzymes is developed. Through the covalent labeling of a sulfonamide inhibitor to the enzyme HCAII via SNAP-tag protein, the enzyme is rendered inactive. Catalytic activation is triggered only when a protease is present to cleave the recognized peptide sequence.
Alkyne-modified biomolecules can be immobilized site- and chemoselectively on sulfonylazide slides under very mild conditions by means of the click sulfonamide reaction.
There are two mol-ecules in the asymmetric unit of the title compound, C(11)H(10)N(3)O(4)S(+)·NO(3) (-). All bond distances have normal values. The C-N bond distances in the sulfonamide group [1.389 (3) and 1.382 (3) Å] may indicate slight conjugation of the sulfonamide N-atom π-electrons with those of the pyridinium ring. The crystal structure is stabilized by N-H⋯O hydrogen bonds.
An automated adaptation of the Bratton-Marshall procedure for sulfonamides has been developed. As sulfonamidesexhibit varying degrees of protein binding, applicahon of the method to plasma is dependent upon release of these compoundsprior to automated dialysis. This release is effected by the acidification of the sample. The results obtained with and without this preliminary acidification are d...
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