نتایج جستجو برای: suicide gene
تعداد نتایج: 1164769 فیلتر نتایج به سال:
Background Elimination of suicide attempts is impossible, but they can be reduced dramatically by an organized planning. The present study aimed to survey the suicide trends in Fars province (Iran), during 2004-2009 to better understand the prevalence and status of suicide. Methods This survey was a cross-sectional study. The demographic data were collected from the civil status registry be...
بررسی ویژگیهای جمعیت شناختی اقدامکنندگان به خودکشی مراجعه کننده به اورژانسهای شهر کرج در سال 1382
Background & Aim: Following the increasing rate of suicide and its outcomes in recent decades, WHO introduced its attempt to decrease suicide rate as one of its aims in world health program by 2000. As a part of multinational project of World Health Organization, this study was undertaken to determine demographic characteristics of suicide attempters attending emergency ward of Karaj Hospit...
The scientific investigation on the role of religion on the suicide rates has begun by the end of the nineteenth century. Nevertheless, these studies have been focused on the comparison of suicide rates between Protestants and Catholics. Given the enormous diminishing effect of Islam on suicide rates within Islamic communities, the history of scientific studies on this issue dates back only t...
Nucleoside analogues (NA) are prodrugs that are phosphorylated by deoxyribonucleoside kinases (dNKs) as the first step towards a compound toxic to the cell. During the last 20 years, research around dNKs has gone into new organisms other than mammals and viruses. Newly discovered dNKs have been tested as enzymes for suicide gene therapy. The tomato thymidine kinase 1 (ToTK1) is a dNK that has b...
Nuclear factor erythroid-2 related factor 2 (Nrf2) is a transcription factor that regulates protection against a wide variety of toxic insults to cells, including cytotoxic cancer chemotherapeutic drugs. Many lung cancer cells harbor a mutation in either Nrf2 or its inhibitor Keap1 resulting in permanent activation of Nrf2 and chemoresistance. In this study, we sought to examine whether this at...
Background & Objectives: Suicide has been recognized as a public health concern in all communities. Several factors are contributing to its incidence in developed and developing countries. Purpose of this study is to investigate seasonal patterns of suicide in Ilam province western Iran. Methods: Data were recruited from a systematic registry of Ilam province between available from 2001–2009. O...
Nucleoside kinases from several species are investigated as suicide genes for treatment of malignant tumors by combined gene/chemotherapy. In the present study, we have investigated a novel strategy where nucleoside kinase proteins are directly delivered to cells without delivery of genetic material. We used a mix of a trifluoroacetylated lipopolyamine and dioleoyl phosphatidylethanolamine (Bio...
The genetic modification of T cells with a suicide gene grants a mechanism of control of adverse reactions, allowing safe infusion after partially incompatible hematopoietic stem cell transplantation (HSCT). In the TK007 clinical trial, 22 adults with hematologic malignancies experienced a rapid and sustained immune recovery after T cell-depleted HSCT and serial infusions of purified donor T ce...
Background & Aims: Suicide in developing countries is an important health problem that occurs at a young age. Our purpose in this study was to compare the suicide trends using epidemiological aspects in Hamadan province in 2006 to 2010. Materials & Methods: The mortality data of suicide for the present study was extracted from the death registry for suicide in District Health Network in Hamada...
Background: The problem of addiction is one of the four global crises. These patients are more vulnerable to mental disorders. This study aimed to examine the risk of suicide in drug dependent patients. Methods: In this cross-sectional study, patients who referred for addiction treatment were selected and the control group was chosen among their companions who did not have narcotic drugs depend...
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