Long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) increases the risk of serious gastroduodenal events. To minimise these risks, patients often require concomitant acid-suppressive therapy. We conducted a literature review of clinical trials examining use of ranitidine 150 mg twice daily to heal gastroduodenal ulcers (GU) in NSAID recipients. Seven studies were identified. After 8 ...

the data (54% vs 90%, respectively) from a Spanish study.1 However, this type of humidification is not recommended in the Centers for Disease Control and Prevention guidelines.4 A semirecumbent body position was reported in 87% of patients, which is a lower percentage compared to that reported in the Spanish study.1 Noninvasive ventilation was used as a first-line treatment in 75% of the ICUs i...

The diagnosis of an intraperitoneal abscess is usually difficult. The clinical manifestation may vary, fever and abdominal discomfort ranging from minimal to severe. Anorexia, nausea, vomiting, and diarrhea or constipation are common features. A 54-year old male, after two weeks hospitalization referred with the diagnosis of appendix infiltrate and melena. He was treated with TPN, omeprazole, s...

Technetium labelled Sucralphate has been used as an ulcer scanning agent in the gastrointestinal tract. The labelling described in the literature involves incubation of Tc99m-HSA (Human serum albumin) with Sucralphate. Due to difficulty in obtaining HSA we used bovine serum albumin (BSA) to tag radioactivity with Sucralphate. The radioactive yields (Tagged Sucraiphate and Tc99m-BSA) obtained af...

OBJECTIVE The aim was to compare the clinical efficacy of lansoprazole with the efficacies of ranitidine and famotidine in order to rank this drug in the hierarchy of duodenal ulcer treatments. METHODS All randomized clinical trials in which lansoprazole was used to treat patients with duodenal ulceration were reviewed. The meta-analysis included a quality assessment for each trial. The main ...

In the past, the attention of physiologists and doctors has been mainly focused on the key role of acid in the pathogenesis of gastroesophageal reflux disease (GERD), but increasing evidence that 20-40% of reflux patients respond not at all or only partially to proton pump inhibitors (PPIs) has underlined the concept that factors other than acid are implicated in its development and the elicita...