Licochalone E is one of the retrochalcones isolated from Glycyrrhiza inflata which shows potent cytotoxicty against human tumor cell lines. Biological studies suggested that topoisomerase I inhibition correlates with cytotoxic properties. Other research revealed that licochalcone E modulats the nuclear factor (NF)-kB and Bcl-2 families to induce endothelial cell apoptosis. Since licochalcone E ...

Chalcones are the primary building blocks for flavonoids and isoflavonoids production. a three-carbon, -unsaturated carbonyl system. form when an aromatic aldehyde reacts with acetophenones in presence of catalyst. For synthesis these molecules, variety methods approaches have been reported. The Aldol condensation Claisen-Schmidt reactions most commonly referenced synthetic protocols literature...

A sulfur-assisted five-cascade sequential reaction, wherein the in situ-generated allenyl allyl sulfides undergo thio-Claisen rearrangement, intramolecular Michael addition, and 1, 5-proton migration/aromatization to obtain allyl thiophen-2-yl acetates, propionates, and ketones as the final products, was reported. As a result of the ready availability of starting materials and the extremely sim...

Several thieno [3,2-d]pyrimidin-4-ones (4a-i) were conveniently prepared by the thio-claisen rearrangement of 5-prop-2-ynylsulfanyl pyrimidin-4-ones derivatives. The constitution of the products was supported by IR, PMR and mass spectral study. The compounds synthesized were tested in vitro against gram positive microorganisms, Bacillus subtilis, Bacillus cereus, Staphlococus aureus, Enterococc...

A simple and efficient method is developed for the zinc catalyzed Claisen rearrangement of allyl aryl ethers to o-allyl phenols by stirring in an oil-bath at 55 °C in liquid phase. Moreover, zinc powder is re-cyclable up to six times use without much loss of significant activity. In addition to it, the products are obtained in good to excellent yields and are in a state of high purity. The stru...

Although Rh(I)Cl(CO)(cpd) (cpd = cyclopentadienone) complexes were identified more than 40 years ago, their exact structures have not been determined because of the polymeric nature of these complexes. We determined the structure of [Rh(I)Cl(CO)(cpd)](2), which was formed by the reaction of [Rh(cod)Cl](2) with a 1,6-diyne under CO. In addition, based on determination of the structure of the [Rh...