نتایج جستجو برای: substitution effect

تعداد نتایج: 1688571  

2011
Anne Decollogny Yves Eggli Patricia Halfon Thomas M Lufkin

BACKGROUND Since generic drugs have the same therapeutic effect as the original formulation but at generally lower costs, their use should be more heavily promoted. However, a considerable number of barriers to their wider use have been observed in many countries. The present study examines the influence of patients, physicians and certain characteristics of the generics' market on generic subs...

Journal: :Physical review letters 2004
H H von Grünberg M Peifer J Timmer M Kollmann

We present a method to quantify spatial fluctuations of the substitution rate on different length scales throughout genomes of eukaryotes. The fluctuations on large length scales are found to be predominantly a consequence of a coarse-graining effect of fluctuations on shorter length scales. This is verified for both the mouse and the human genome. We also found that the relative standard devia...

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