OBJECTIVES/HYPOTHESIS To investigate epidemiological features and symptoms of sialolithiasis and their implications for diagnosis and management. STUDY DESIGN Retrospective cohort study. METHODS Retrospective analysis on 2,322 patients with sialolithiasis, between 1987 and 2009. The statistical significance between two sample distributions was computed using analysis of variance Student t t...

We reviewed the clinical history of 48 consecutive patients who underwent submandibular gland removal for radiologically proven sialolithiasis. The specimens were examined by a pathologist blinded to the clinical data. A histopathologic classification into I of 3 grades was established by evaluating the degrees of atrophy, fibrosis, and inflammation. A correlation between the clinical and patho...

In this paper an unusual case of lymphadenopathy associated with Actinomyces infection is reported. In the literature, there are only two cases presented with histopathologic features. A forty-year-old male patient was admitted to the hospital with painless mass on the neck. Clinical examination revealed a firm mass on the right submandibular region. The patient had no malignancy history. A cys...

OBJECTIVES/HYPOTHESIS Salivary gland stones (sialoliths) are a common cause of salivary gland enlargement, but such stones are uncommon in children. Low-flow vascular malformations of the head and neck region may develop phleboliths. Phleboliths within a venous malformation may be mistaken for a salivary stone given the similar calcified nature and location. We present two children who were ref...

The clinical diagnosis of Parkinson disease (PD) is incorrect in 30% or more of subjects particularly at the time of symptom onset. Because Lewy-type α-synucleinopathy is present in the submandibular glands of PD patients, we assessed the feasibility of submandibular gland biopsy for diagnosing PD. We performed immunohistochemical staining for Lewy-type α-synucleinopathy in sections of large se...

A 48-year-old man who had a complaint of swelling in the left submandibular region and right side of the neck was referred to our radiology clinic for sonographic examination that revealed a type 1 hydatid cyst with a diameter of 32 mm in the left submandibular gland, and a type 3 hydatid cyst with a diameter of 33 mm in the right thyroid gland. The diagnosis was verified by computed tomography...

OBJECTIVE To determine the frequency of submandibular gland involvement in early oral cavity tumors. STUDY DESIGN Observational study. PLACE AND DURATION OF STUDY ENT Department, CMH, Rawalpindi, from January 2008 to December 2011. METHODOLOGY Data of 110 oral cavity tumors operated over 2008 - 2011 was retrieved from ENT OPD, tumor registry in AFIP and from Head and Neck Oncology Forum R...

Calorie restriction reduces mammary mitogenesis and tumorigenesis. To test whether epidermal growth factor (EGF) levels are influenced by calorie intake, 72 four-week-old C3H/HeOu mice were separated into two groups and either fed ad libitum (group AL) or calorie-restricted at a mean 19% (group CR). Three mice from each group were evaluated when 6, 8, 10, and 12 weeks old for submandibular glan...

INTRODUCTION Sialolithiasis is the most common cause of salivary gland disease and about 80% to 90% of stones occur in the submandibular gland (SMG). Among them, 40% of the SMG stones are located in the distal submandibular duct near the punctum, and they are removed through the intraoral approach. The other 60% of the SMG stones are located in the proximal submandibular duct or in the submandi...