The aim of our study was to determine to what degree one-year exposure of female rats to cadmium at a dose of 5, 50 and 100 mg Cd/l affects cell proliferation in the submandibular gland, shown by PCNA and Ki-67 expression. In the present study, we found a positive nuclear reaction for PCNA in single cells in microscopic preparations of control rats. In Group I, an increase was observed in the n...

A 25-year-old female was referred to the Haematology Unit at Tygerberg Hospital for further management of a rapidly expanding and large submandibular mass which on fine needle aspiration was suggestive of lymphoma (Figure 1). Five months earlier she had been diagnosed with pulmonary tuberculosis and was confirmed to be HIV positive with a CD4 count of 17. She was placed on anti-retroviral (ARV)...

Desmoid fibromatosis is a benign yet locally aggressive tumor with a tendency to recur. It causes considerable morbidity particularly when it arises in a small area in the head and neck region. This tumor is extremely rare in the submandibular region. We report a case of desmoid tumor in the submandibular region in a 32-year-old male who presented with right submandibular swelling postextractio...

Introduction Sialolithiasis is the formation of a calcified mass (sialolith) in the salivary glands. It is said to affect 0.1 to 1% of the population with a male predilection and 30 to 60 years being the most common age. (1)Of all the salivary glands, sialoliths are most commonly found in the submandibular gland (80-95%) (2). This is owing to longer, tortuous Wharton's duct, anti-gravity flow o...

A ranula is a bluish, transparent, and thin-walled swelling in the floor of the mouth. They originate from the extravasation and subsequent accumulation of saliva from the sublingual gland. Ranulas are usually limited to the sublingual space but they sometimes extend to the submandibular space and parapharyngeal space, which is defined as a plunging ranula. A 21-year-old woman presented with a ...

Adenoid Cystic Carcinoma of the Submandibular Gland Yong-Yun Ha, Seong-Gon Kim, Min-Keun Kim Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University Adenoid cystic carcinoma is a distinctive neoplasm of the salivary gland and is the most common malignant tumor of submandibular gland. Although adenoid cystic carcinoma grows slowly, it shows aggress...

A 67-year-old man with a history of asbestos exposure and rounded atelectasis complained of cough and swelling in the left submandibular region. Computed tomography showed an increase in size of the right lower lung lobe lesion, which was recognized as the pre-existing rounded atelectasis, as well as swelling of the pancreas and submandibular glands. Biopsy from a submandibular gland and the pu...

The aim of this study was to clarify the effects of the muscarinic receptor agonist, cevimeline, on saliva flow and expression of aquaporin5 (AQP5) in submandibular gland after X-ray irradiation. Using a previously established radiation-induced xerostomia model mouse, saliva flow from at 7 days before irradiation to at 28 days after irradiation was investigated in mice that were treated with ce...

Introduction A 10-year-old girl developed an enlargement of parotid and submandibular salivary glands and lymph nodes up to 2.5 cm associated with edema of her upper eyelids. In further follow-up, she developed non-palpable, vasculitic skin lesions. She received cephixime, that co-incided with partial regression of lymph nodes. Re-occurrence of vasculitic lesions with bilateral edema of upper e...

OBJECTIVE To test the validity of the reported high incidence (50%) of malignancy in neoplasms of the submandibular salivary gland, and to compare it with that of the parotid gland. METHODS This is a retrospective analysis of major salivary gland neoplasms in 127 patients who were treated between August 1988 and December 2004 (15 1/2 years) at Kalafong Hospital, Pretoria. RESULTS All but 1 ...