the purpose of this study was to compare the efficacy and safety of misoprostol and oxytocin for induction of labor. in this prospective and randomized controlled trial one hundred twenty women with an unfavorable cervix who underwent labor induction were assigned to receive either intravenous high dose oxytocin(6miu/min) or intravaginal misoprostol 50µg every 6 hours for two doses. twelve hour...

CONTEXT Misoprostol was used by women across Mexico to induce abortion even before 2007, when first-trimester abortion was legalized in Mexico City. Pharmacy vendors' misoprostol recommendation practices across subregions of Mexico after abortion legalization warrant examination. METHODS Overall, 192 pharmacies in four regions of Mexico were randomly selected and visited by simulated clients ...

postpartum hemorrhage is an important cause of maternal morbidity and mortality after delivery. active management of postpartum hemorrhage by an uterotonic drug decreases the rate of postpartum hemorrhage. the aim of this study is to evaluate the efficacy of rectal misoprostol for prevention of postpartum hemorrhage. this double blind randomized clinical trial was performed on full term pregnan...

objective: to compare efficacy, safety and tolerance of combination of mifepristone and misoprostol versus misoprostol-only in induction of late intrauterine fetal death (iufd). materials and methods: this prospective study included a consecutive series of 52 women gravid up to fourth with iufd after 28 weeks of gestation between january 2008 and june 2011. women were divided into two groups. f...

OBJECTIVE To review maternal deaths and the dose-related effects of misoprostol on blood loss and pyrexia in randomized trials of misoprostol use for the prevention or treatment of postpartum haemorrhage. METHODS We searched the Cochrane Controlled Trials Register and Pubmed, without language restrictions, for '(misoprostol AND postpartum) OR (misoprostol AND haemorrhage) OR (misoprostol AND ...

OBJECTIVE To analyze published randomized trials assessing the safety and efficacy of misoprostol for cervical ripening and labor induction. DATA SOURCES We supplemented a search of entries in electronic data bases with references cited in original studies and review articles to identify randomized trials of misoprostol for cervical ripening and labor induction. METHODS OF STUDY SELECTION T...

OBJECTIVE To validate anecdotal reports that abortion-related complications decreased in the Dominican Republic after the introduction of misoprostol into the country. DESIGN Retrospective records reviews and cross-sectional surveys, interviews and focus groups. SETTING Family planning clinics, pharmacies, door-to-door canvassing and a tertiary care maternity hospital in Santo Domingo, Domi...

INTRODUCTION In Ethiopia, postpartum hemorrhage is a leading cause of maternal death. The Maternal Health in Ethiopia Partnership (MaNHEP) project developed a community-based model of maternal and newborn health focusing on birth and early postpartum care. Implemented in the Amhara and Oromiya regions, the model included misoprostol to prevent postpartum hemorrhage. This article describes regio...

BACKGROUND Misoprostol has become a popular over the counter self-administered abortifacient in Ghana. This study aimed to compare the socio-demographic characteristics and clinical complications associated with misoprostol and non-misoprostol induced abortions among patients admitted to a tertiary public health facility in Ghana. METHODS This was a cross sectional study conducted at the gyna...

OBJECTIVE To compare the safety and efficacy of misoprostol with that of dinoprostone for the induction of labour at term, or near term. DESIGN Three hundred and ninety-six women with term pregnancies were randomised to receive either oral or vaginal misoprostol, or dinoprostone. Women who had had a previous caesarean section (CS) or those with a malpresentation or who were parity > or = 5, w...