OBJECTIVE Pinus eldarica (P. eldarica) is one of the most common pines in Iran which has various bioactive constituents and different uses in traditional medicine. Since there is no documented evidence for P. eldarica safety, the acute and sub-acute oral toxicities of hydroalcoholic extract of P. eldarica bark were investigated in male and female Wistar rats in this study. MATERIALS AND METHO...

Background: Seabuckthorn (SBT, Hippophae rhamnoides L.) is an important medicinal plant of cold desert areas. Therapeutic significance of various parts of this plant has been mentioned in many traditional medicinal systems, especially Chinese and Tibetan systems. There are many pharmacological reports suggesting therapeutic usefulness of SBT leaf extracts, however, relatively very few toxicity ...

OBJECTIVES The goals of this research were to evaluate acute (single-dose) and sub-acute (repeated-dose) toxicity profiles of methanolic extract of Pistacia integerrima J. L. Stewart ex Brandis (PI) for Wistar rats and to assess the safety profile of PI by observing physiological changes, mortality, changes in body weight, the histopathology of body organs, the hematology and the biochemistry o...

Article history: Received on: 21/10/2016 Accepted on: 24/01/2017 Available online: 30/05/2017 The present study was carried out to evaluate the safety of Asparagus racemosus root ethanol extract, isoprinosine and shatvari syrup by acute ad subacute toxicity studies. Acute and subacute oral toxicity study was conducted according to the guidelines of OECD 425 and 407 respectively. In acute oral t...

Purpose: Ageratum conyzoides is an annual herbaceous plant commonly used in African traditional medicine as a purgative, antipyretic, anti-ulcer and wound dressing agent. The objective of this study was to investigate the acute and sub-chronic toxicity of A. conyzoides leaves in Wistar rats. Methods: In the acute test, the limit test dose of 5000 mg/kg was administered to Wistar rats and then o...

Mercuric chloride was introduced per Os in albino rats (Rattus norvegicus) as the LD50 (9.26 mg/kg b.w.). The assessment of mercuric toxicity done both after acute (0.926 b.w.) and sub-acute (0.033 treatment, while Panax ginseng also (10 separately. treatment significantly increases mercury retention liver blood serum along with increase weight, alone caused significant decrease weight blood. I...

The acute and sub-acute toxicity of safranal were studied in rat and mice within 2 and 21 days after exposure, respectively. For subacute toxicity, changes in weight as well as biochemical, hematological and pathological parameters were studied. The intraperitoneal LD50 values of safranal were 1.48 mL/kg in male mice, 1.88 mL/kg in female mice and 1.50 mL/kg in male rats. Oral LD50 values were ...

This study aims to assess the acute and sub-chronic oral toxicity of “Tri 02” powder in experimental animals. According World Health Organization Guidance, was conducted using Swiss mice. LD50 determined by Litchfield-Wilcoxon method, at two doses (2.4 g/kg b.w/day 7.2 b.w/day) assessed Wistar rats for four uninterrupted weeks. Abnormal behavior, toxic symptoms, death were observed 7 consecutiv...