background: the poor permeability of the plasma and nuclear membranes to dna plasmids are two major barriers for the development of these therapeutic molecules. therefore, success in gene therapy approaches depends on the development of efficient and safe non-viral delivery systems. objectives: the aim of this study was to investigate the in vitro delivery of plasmid dna encoding hpv16 e7 gene ...

Lin et al. examined the effects of lipid chains attached to N-terminal antimicrobial peptides, a type membrane-active on their membrane activity and bioactivity. The impact lipidation varied depending original peptides' hydrophobicity. By altering peptide conformations affecting self-aggregation behaviours, changed peptide-biomembrane interaction, ultimately bioactivity (e329).

Background: Vasoactive intestinal peptide (VIP) is an important neurotransmitter involved in the modulation of gastrointestinal function through stimulation VIP receptors. However, expression VPAC1R, VPAC2R and PAC1R human Lower esophageal sphincter (LES) has not been fully clarified. Therefore, purpose this study to explore these receptors sphincter, responses peptide, role responses.

The present work describes the engineering of anti-PSMA peptide-decorated exosome mimetics (EMs) targeting advanced prostate cancer (PC). targeted EMs were produced from peptide, WQPDTAHHWATL, expressing U937 monoblastic cells, followed by successive extrusion cycles. engineered nanosized, at a high yield, and displayed exosomal markers monocytes proteins on their surface. As anticipated, PSMA-...

Objective: Cancer has risen as the main cause of diseases with the highest rate of mortality in the world. Drugs used in cancer, usually demonstrate side effects on normal tissues. On the other hand, anticancer small peptides, effective on target tissues, should be safe on healthy organs, as being naturally originated compounds. In addition, they may have good pharmacokinetic properties. carnos...

Single chain Fragment variable (scFv) is an antibody fragment consisting variable regions of heavy and light chains. scFvs enhance their penetrability into tissues while maintaining specific affinity and having low immunogenicity. Insoluble inclusion bodies are formed when scFvs are expressed in reducing bacterial cytoplasm. One strategy for obtaining functionally active scFv is to translocate ...

The novel coronavirus, SARS-CoV-2, broken out as the COVID-19 epidemic, is transported into cytoplasm by angiotensin-converting enzyme-2 (ACE2), a key protein of renin-angiotensin-system (RAS). ACE2 protective that reduces angiotensin (Ang) II, bioactive component RAS, converting it to its potent antagonist, Ang-(1-7) peptide, in order provide pathophysiological response stimuli. Although ACE-2...

Abstract Background Malnutrition is a common finding after major abdominal surgeries especially prolonged period of fasting in children. Enteral feeding the commonest support way postoperatively for stimulating gut hormones, modulating immunity, and maintaining barrier function intestinal mucosa. Our aim was to compare results outcome regarding tolerance, nutritional status, hospital stay follo...

Peptide-based strategies have received an enormous amount of attention because their specificity and applicability. Their tumor-targeting ability are applied to diagnosis treatment for cancer patients. In this review, we will summarize recent advancements future perspectives on peptide-based treatment. The literature search was conducted identify relevant articles It performed using PubMed in E...

introduction: influenza a virus causes unpredictable epidemics and pandemics by creating antigenic variations. with the appearance of each new strain, rapid emergency countermeasures are taken against this new strain. hence, designing an applicable and cross protective strategy to counter this virus is of great importance. to achieve this, choosing conserved antigenic regions in influenza virus...