DNA methylation is an epigenetic mechanism for transcriptional regulation. The methylation process controls cellular differentiation and is defective in many diseases including cancer. Therefore, the development of a simple method for analysing cytosine methylation in a target gene is required. Here we report a conceptually new method for sequence-selective chemical modification of a single cyt...

GWAS studies have been successful in finding genetic determinants of obesity. To translate discovered genetic variants into new therapies or prevention strategies, molecular or physiological mechanisms need to be discovered. One strategy is to perform data mining of data sets with detailed phenotypic data, such as those present in dbGAP (database of Genotypes and Phenotypes) for hypothesis gene...

Methylated DNA plays an important role in epigenetic gene regulation, and could therefore serve as a potentially promising biomarker for the diagnosis of cancer and other diseases. Therefore, the development of a simple method for analyzing cytosine methylation in a target gene is required. Here, we report on a new method for the sequence-selective chemical modification of a single cytosine in ...

We present a novel methodology for performing experiments with subsurface structural models using a set of flexible and extensible Python modules. We utilize the ability of kinematic modelling techniques to describe major deformational, tectonic, and magmatic events at low computational cost to develop experiments testing the interactions between multiple kinematic events, effect of uncertainty...

rangeland ecosystem contains various patches with different functions. structural and functional characteristics of rangeland patches are changed by management practices and can be used to interpret management effects. the structural and functional characteristics of fertilized patches in two rangeland ecosystems of ghareh ghir and maraveh tapeh were measured and analyzed in this study. a group...

The chemical modification of histones at specific DNA regulatory elements is linked to the activation, inactivation and poising of genes. A number of tools exist to predict enhancers from chromatin modification maps, but their practical application is limited because they either (i) consider a smaller number of marks than those necessary to define the various enhancer classes or (ii) work with ...

Given metric spaces (X,DX) and (Y,DY ), an embedding F : X → Y is an injective mapping from X to Y . Expansion eF and contraction cF of an embedding F : X → Y are defined as eF = max x1,x2( 6=x1)∈X DY (F (x1), F (x2)) DX(x1, x2) and cF = max x1,x2( 6=x1)∈X DX(x1, x2) DY (F (x1), F (x2)) , respectively and distortion dF is defined as dF = eF ·cF . Observe that dF ≥ 1. An embedding F : X → Y is n...

background: candida albicans is one of the most important opportunistic pathogens that suppress immunologic mechanisms of the host. it is speculated that structural and secretory proteins of c. albicans have immunomodulatory effects in cancer. objective: to evaluate the effects of c. albicans structural and secreted proteins on intratumoral cd4/cd8 ratio as well as the survival rate in balb/c t...