The institute’s prime objective and mission is to contribute actively to a working life that offers good conditions and development opportunities for women and men. We work to promote a healthy working environment that is adapted to people’s different physical and mental needs and capacity. This we do in collaboration with the social partners and professionals who are actively involved in issue...

A touch of impatience can be discerned amongst realistically oriented colleagues in this series of essays: formal philosophers and economists have injected a certain a priori and deductive element into the discussion of trust. The description of the manner in which trust and hence economic vitality were deliberately destroyed by Neapolitan political authority is a welcome corrective (Pagden, th...

A core task in computational structural biology is the search of conformational space for low energy configurations of a biological macromolecule. Because conformational space has a very high dimensionality, the most successful search methods integrate some form of prior knowledge into a general sampling algorithm to reduce the effective dimensionality. However, integrating multiple types of co...

A new method for the selective chemical modification of DNA at cytosine nucleobases using alkoxy- and benzyloxyamines is presented. It is shown that in particular benzyloxyamines are effective DNA modifying agents, giving rise to almost exclusive formation of the mono addition products. By using a bifunctional derivative, that is, p-azidobenzyloxyamine hydrochloride, an azide moiety, which is a...

Generalized structured component analysis (GSCA) is a component-based approach to structural equation modeling (SEM), where latent variables are approximated by weighted composites of indicators. It has no formal mechanism to incorporate errors in indicators, which in turn renders components prone to the errors as well. We propose to extend GSCA to account for errors in indicators explicitly. T...

We propose a new causal parameter, which is a natural extension of existing approaches to causal inference such as marginal structural models. Modelling approaches are proposed for the difference between a treatment-specific counterfactual population distribution and the actual population distribution of an outcome in the target population of interest. Relevant parameters describe the effect of...

Even though practitioners and researchers generally agree that project management methodologies are very useful in managing IT-related projects, organizations are rarely able to motivate their staff to use them. Even when employees use these methodologies, the question of how they are being used still remains. To better understand the way in which employees use project management methodologies,...

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Bromomaleimides are useful building blocks in synthesis and powerful reagents for the selective chemical modification of proteins. A mild new synthesis of these reagents is described, along with the convenient transferability of the approach to dithiomaleimides and bromopyridazinediones.