objectives due to the known anti-oxidant and anti-diabetic effects of origanum majorana (om), this study was conducted to survey its effects on oxidative stress and histopathology of renal tissue among diabetic rats. materials and methods in this experimental investigation, 32 male rats, weighing 200 - 250 g, were divided into four groups: 1: control, 2: control receiving treatment with om, 3: ...

objective: oxidative stress plays an important role in the development of diabetic complications including metabolic abnormality-induced diabetic micro-vascular and macro-vascular complications. urtica dioica l. (u. dioica) has been traditionally used in iranian medicine as an herbal remedy for hypoglycemic or due to its anti-inflammatory properties. the aim of the present study was to evaluate...

the objective of this study was to evaluate the impact of short-term starvation and re-feeding on oxidative stress in mesopotamichthys sharpeyi (günther, 1874). after two weeks adaptation to new conditions, a total number of 270 fingerlings were distributed into nine 300-l fiberglass tanks, equipped with aeration system in three treatments including 4, 8 and 16 days starvation (each in 3 replic...

fenpropathrin is a new pyrethroid insecticide used to control crop pests. the aim of this study was to evidence fenpropathrin-induced oxidative stress and alterations in biochemical parameters in the freshwater fish, alburnus mossulensi s. total antioxidant capacity, malondialdehyde (mda), catalase activity (cat), aspartate aminotransferase (ast), alanine aminotransferase (alt), alkaline phosph...

to study the anticoccidial and antioxidant effects of garlic powder (gp) and total sulfur amino acid (tsaa) on growth performance, faecal oocyst output, oxidative stress indicators and antioxidant status markers in broiler chickens, a 2 × 2 × 2 splitplot-factorial arrangement of treatments was used. a total of 480-day-old male broiler chickens were equally assigned to two plots. two hundred for...

several studies have shown that hepatocyte membrane composition changes in patients with cholestasis and cirrhosis. these alterations that are because of intracellular oxidative stress are supposed to be reflected in erythrocyte membrane. the aim of this study was to investigate the modification of erythrocyte membrane along with hexokinase and antioxidant enzymes during development of cirrhosi...

compelling evidence suggests that the oxidative stress plays a key role in the pathophysiology of cardiovascular disease (cvd). superoxide dismutase (sod) enzymes play a major role in detoxification of reactive oxygen species and protection against oxidative stress. we examined the possible association between a 50-bp insertion/deletion in the sod1 promoter 1684-bp upstream of the sod1 atg with...

alzheimer’s disease (ad) is a progressive neurodegenerative disorder that affects regions of the brain that control cognition, memory, language, speech and awareness to one’s physical surroundings. the pathological initiation and progression of ad is highly complex and its prevalence is on the rise. in his study, alzheimer's disease was induced with single injection of amyloid-β (aβ) pepti...

diazinon is an organophosphate which is extensively used in trade and agriculture. due to its widespread application, its toxicity is common. several studies have shown that organophosphates are able to induce oxidative stress by generating free radicals and depletion of endogenous antioxidants. pomegranate seed oil (pso) possesses anti-inflammatory and antioxidant effects. in this study, the e...

dacarbazine is an antitumor prodrug which is used for the treatment of malignant metastatic melanoma and hodgkin’s disease. it requires initial activation in liver through an n-demethylationreaction. the active metabolite prevents the progress of disease via alkylation of guanine bases in dna strands. in order to investigate the importance of imidazole ring and its dynamictautomerization in ant...