abstract background and objective: it has been shown that oxidative stress increases in diabetes and it has an important role in its development and subsequent complications. thus, the aim of this study was to investigate the effect of acute resistance exercise on oxidative stress in skeletal muscle and cardiac tissues of streptozotocin-induced diabetic rats. materials and methods: twenty male ...

background: the present study evaluated the effects of treadmill running on extracellular basal levels of glutamate and gaba at dentate gyrus of streptozotocin-induced diabetic rats. methods: after 12 weeks of diabetes induction and exercise period, extracellular levels of glutamate and gaba were investigated. results: the results showed that glutamate levels were significantly decreased in dia...

Herbal medicine development against the non-communicable disease like diabetes is one of the thrust area of research in the field of global medicine. Here we have studied the separate and composite methanolic extract of seed of Eugenia jambolana and root of Musa paradisiaca for the management of streptozotocin-induced diabetes mellitus. We have measured the fasting blood glucose level and glyco...

Biosynthesis of niacin from 3-hydroxyanthranilic acid (3-OHAA) in normal and streptozotocin diabetic rats was studied in vivo and in vitro. Streptozotocin (SZ) diabetic rats were found to excrete lesser quantities of 3-OHAA, quinolinic acid, niacin and N1-methylnicotinamide (nmn) in their urines following 3-OHAA administration than corresponding normal rats. In vitro studies indicated that SZ d...

remained above the range to be expected with his blood sugar values. A possible explanation is that some islet cell tumours produce abnormal insulins which are biologically inactive but not immunologically distinct (Samols, 1965). The principal aim of streptozotocin therapy for malignant insulinoma is the restoration of normoglycaemia. This has been achieved in all reported cases. More radical ...

Low-dose streptozotocin-induced diabetes in mice serves as a model of type I diabetes. Suppression of the development of diabetes (hyperglycemia) in C3H/He mice was achieved with in vivo administration of antibody reactive to Ir-gene products before streptozotocin treatment. A persistent effect was reached with two monoclonal antibodies directed against I-Ak gene products and, surprisingly, by ...

Purpose: To explore the antidiabetic potential of Moringa oleifera leaf extract in type 2 diabetic rats, and underlying mechanisms.Methods: Streptozotocin (STZ) at a dose 40 mg/kg was given to high fat diet (HFD)- fed rats induce diabetes. M. doses 100, 200 400 were 3 groups rats. The area under curve (AUC) glucose homeostasis model assessment insulin resistance (HOMA-R) calculated using approp...

Given the promising good future of selenium nanoparticles in modern field health, have played an important role increasing sperm efficacy and antioxidant defense mechanisms. In present study, we synthesized (Se NPs) a safe harmless medical manner from aqueous extract Withania somnifera roots. The formation Se NPs was confirmed using different techniques spectroscopy. results showed broad absorp...

the hypoglycemic effect of the ethanolic extract of Momordica charantia (cucurbitaceae) was investigated in both normal and streptozotocin - induced diabetic mice. The ethanolic extract of Unriped fruits of M. charantia (800mg/kg) reduced the blood glucose of normal mice from 172 ±3 to 136 ± 5 mg/100ml 4 hours after intrapertitoneal administration (P<0.001), and also significantly lowered the b...

Eleven antidiabetic Indian medicinal plants were investigated in streptozotocin induced diabetic rat model and provided scientific validation to prove their antihyperglycemic activity. Antidiabetic principles from five plants were isolated. All the compounds isolated were evaluated for antihyperglycemic activity in streptozotocin induced diabetic rat model and activities were compared with stan...