Objective: PDE5 inhibitors represent the first line therapy for treatment of ED. However, diabetic patients have poorer response compared with normal patients. The aim of this study was to determine whether taurine, a sulfurcontaining amino acid, affects diabetic erectile dysfunction. Methods: Type 1 diabetes mellitus was induced in male rats by streptozotocin (60 mg/kg, intraperitoneally). Aft...

Impaired heart function is the main reason for increased mortality of diabetes mellitus. Development of drugs with cardioprotective effects against diabetic myocardiopathy would benefit patients with diabetes. In this study, we tested the cardioprotective effects of Daming capsule (DMC), a traditional Chinese formula, on heart function in streptozocin (STZ)-induced diabetic rats with high fat-d...

1National Research Center, Complementary Medicine, Cairo, Giza 12311, Egypt; 2National Research Center, Medical Biochemistry, Cairo, Giza 12311, Egypt; 3National Research Center, Cultivation and Production of Aromatic and Medicinal Plants, Cairo, Giza 12311, Egypt; 4Gizan University, Medical Applied Science, Medical Chemistry, Gizan, Saudi Arabia; 5National Research Center, Histology and Pathol...

BACKGROUND Type 1 diabetes mellitus (T1DM) is associated with increased risks of enteric infection. Paneth cells constitute the first line of the gut defense. Little is known about the impact of T1DM on the bactericidal function of intestinal Paneth cells. MATERIAL AND METHODS A T1DM mouse model was induced by intraperitoneal injection of streptozocin. The analysis of intestinal microbiota and ...

The activity of the enzyme O6-alkylguanine-DNA-alkytransferase (AGAT) protects cells from the cytotoxic effects of alkylating agents. This Phase II trial was designed to assess the efficacy of a strategy designed to modulate the resistance to carmustine (BCNU) mediated by AGAT using streptozocin (STZ) in patients with advanced refractory melanoma. Seventeen patients who had failed prior chemoth...

Apoptosis plays critical role in diabetic cardiomyopathy and endoplasmic reticulum stress (ERS) is one of intrinsic apoptosis pathways. For previous studies have shown that endoplasmic reticulum become swell in diabetic myocardium and ERS was involved in diabetes mellitus and heart failure, this study aimed to demonstrate whether ERS was induced in myocardium of streptozocin (STZ)-induced diabe...

The activity of the enzyme 06-alkylguanine-DNAalkytransferase (AGAT) protects cells from the cytotoxic effects of alkylating agents. This Phase II trial was designed to assess the efficacy of a strategy designed to modulate the resistance to carmustine (BCNU) mediated by AGAT using streptozocin (STZ) in patients with advanced refractory melanoma. Seventeen patients who had failed prior chemothe...

Background: Adipose tissue pathology plays a crucial role in the pathogenesis of type 2 diabetes mellitus. Understanding impact exercise training on adipose adaptation is paramount importance enhancing metabolic health. In this study, we aimed to investigate effects various modalities three distinct depots, namely, interscapular brown (iBAT), subcutaneous white (sWAT), and epididymal (eWAT), mu...

Jeremy A. Lavine,* Carly R. Kibbe,* Mieke Baan, Sirinart Sirinvaravong, Heidi M. Umhoefer, Kimberly A. Engler, Louise M. Meske, Kaitlyn A. Sacotte, Daniel P. Erhardt, and X Dawn Belt Davis School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin; Department of Medicine, Division of Endocrinology, University of Wisconsin-Madison, Madison, Wisconsin; Geriatric Res...