Pelvic organ prolapse (POP) is a common condition affecting almost half of women over the age of 50. The molecular and cellular mechanisms underlying this condition, however, remain poorly understood. Here we have reported that fibulin-5, an integrin-binding matricellular protein that is essential for elastic fiber assembly, regulated the activity of MMP-9 to maintain integrity of the vaginal w...

Short tandem repeats (STRs) are highly mutable genetic elements that often reside in regulatory and coding DNA. The cumulative evidence of genetic studies on individual STRs suggests that STR variation profoundly affects phenotype and contributes to trait heritability. Despite recent advances in sequencing technology, STR variation has remained largely inaccessible across many individuals compa...

What is a pop-up store and how can it be used for organisational counterspacing? The pop-up can be interpreted as a fashionable and hypermodern platform focusing on the needs of a younger generation of consumers that searches for new experiences and is prone to ad hoc decision-making. From this perspective, the pop-up is a typical expression of the experience economy. But it is more. The epheme...

ELENA MIHAELA CARAUSU1, VIOLETA TRANDAFIR2,3*, LAURA GHIBU4,5*, OVIDIU STAMATIN6, LAURA ELISABETA CHECHERITA7 1Grigore T. Popa University of Medicine and Pharmacy, Faculty of Dental Medicine, Department of Management and Public Health Dentistry, 16 Universitatii Str, 700115, Iasi, Romania 2 Grigore T. Popa University of Medicine and Pharmacy, Faculty of Dental Medicine, Department of Oral and M...

We introduce Space-Time Routing (STR), a new approach to routing in mobile ad hoc networks. In STR, the age of routing state is considered jointly with the distance to the destination. We give a general description of STR, which can accommodate various temporal (age) and spatial (distance) metrics. Our formulation of STR describes a family of routing algorithms, parameterized by a choice of nod...

FELICIA DRAGAN1, IRINA KACSO2, FLAVIA MARTIN2*, GHEORGHE BORODI2, IOAN BRATU2, MARCEL COSTULEANU3, IOAN GABRIEL SANDU4,5*, VLADIMIR POROCH6,7 1 Oradea University, Faculty of Medicine and Pharmacy, 1 Armatei Romane Str., 410087, Oradea, Romania 2 National Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donat Str., 400293, Cluj Napoca, Romania, 3 Grigore T. P...

This paper presents the development of a Genetic Algorithm Supervisory Loop (GASL) to enhance the performance of Adaptive Controllers in the Self Tuning Regulator (STR) framework. The GASL is designed to tune the identification model and control parameters to achieve an optimum performance of the process. The STR controller used to demonstrate the technique effectiveness is a real time Proporti...

In the nematode Caenorhabditis elegans, a canonical Wnt signaling pathway controls a cell migration whereas noncanonical Wnt pathways control the polarities of individual cells. Despite the differences in the identities and interactions among canonical and noncanonical Wnt pathway components, as well as the processes they regulate, almost all C. elegans Wnt pathways involve the sole Tcf homolog...

In this study, we aim to conduct usability tests on different WebMap sites with eye movement analysis. Overall task performance, the effects of iconic representation of information, and the efficiency of pop-up usage were evaluated. The eye tracking technology is used for this study in order to follow the position of the users’ eye-gaze. The results show that there are remarkable differences in...