In Cnidaria, the production of neurotoxic polypeptides is attributed to the ectodermal stinging cells (cnidocytes), which are discharged for offensive (prey capture) and/or defensive purposes. In this study, a new paralysis-inducing (neurotoxic) protein from the green hydra Chlorohydra viridissima was purified, cloned, and expressed. This paralytic protein is unique in that it (1) is derived fr...

The results of a randomised double-blind clinical trial of 3% acyclovir and 0.5% idoxuridine (IDU) ophthalmic ointments in 60 patients with corneal dendritic ulceration are presented. Ulcers in all 30 patients treated with acyclovir healed compared with 22 (76%) of 29 patients treated with IDU (P < 0.01). Patients treated with acyclovir healed more rapidly (average 4.4 days) than those who rece...

INTRODUCTION This study investigated scorpionism profile in the State of Amazonas, Brazil. METHODS Data referring to stinging incidents were obtained from the National Databank of Major Causes of Morbidity. Information on the scorpion species involved was obtained from the Amazonas State health units. RESULTS Amazonas has a scorpionism rate of 8.14 cases/100,000 inhabitants. Some municipali...

AIMS To measure pimecrolimus blood concentrations and to evaluate tolerability and efficacy in children and infants treated topically for atopic dermatitis with pimecrolimus cream 1% for three weeks. METHODS Three open label, non-controlled, multiple topical dose studies were conducted in children aged 8-14 years (study A, ten patients), and in infants aged 8-30 months (study B, eight patient...

A number of repellent compounds produced by plants elicit a spicy or pungent sensation in mammals . In several cases, this has been found to occur through activation of ion channels in the transient receptor potential (TRP) family . We report that isothiocyanate (ITC), the pungent ingredient of wasabi, is a repellent to the insect Drosophila melanogaster, and that the painless gene, previously ...

ERα LBD structures may explain instability in the absence of ligand or with specific ligands 1,2,7,9. Nettles et al. 5 address this instability through use of a specific point mutation, Y537S, which stabilizes H12 in an agonist con-formation and is shown to overcome misfold-ing of the apo-ERα LBD. One might predict that stabilizing H12 on top of the ligand binding cavity with the Y537S mutation...

Abstract Sauvignon Blanc represents an important grape variety. The wine made from this variety is known to have a wide range of aroma profiles nettles tropical fruits. Beside the raw material quality (grapes), wines can be fundamentally influenced by technological conditions applied in making process. Yeast and other microorganisms play key role formation metabolites during alcoholic fermentat...