Background Scorpion stings are the most important health problems in tropical and subtropical countries. The aim of this study was to assess spatial distribution of scorpions and scorpionism in Ardabil province, Iran. Materials and Methods This descriptive–analytic study wascarried out in all 10 counties of Ardabil province, Northwestern Iran.The clinical and demographic data of scorpion sting ...

BACKGROUND Contact with jellyfish can cause skin irritation and manifestations. We wanted to investigate the prophylactic effect of a sun cream containing an inhibitor against jellyfish stings. MATERIAL AND METHOD We recruited 38 persons who were randomised such that each received two of three possible treatments, one on each underarm. Prophylactic treatment with sun cream containing jellyfis...

A thesis in partial fulfilment of the requirements for the degree of Doctor Philosophiae Επισκεπτεον δε µαλλον και περι του ηγεµονος, ει κεντρον εχει η µη. (But further enquiry is necessary in fact about the leader, as to whether he has a sting or not)

Scorpion envenomations represent an actual public health problem in Algeria, at various levels, in three-fourths of the country provinces. A total of 903, 461 scorpion sting cases and 1996 induced deaths were reported in the country between 1991 and 2012. As the scorpion envenomation surveillance is based on passive system, the present study aims to analyse and to interpret the reported scorpio...

The parasitoid wasp Ampulex compressa induces a set of unique behavioral effects upon stinging its prey, the cockroach. It stings into the first thoracic segment inducing 2 to 3 min of transient flaccid paralysis of the front legs. This facilitates a second sting in the cockroach's head that induces 30 min of excessive grooming followed by a 2 to 5-week long lethargic state. In the present stud...

Activation of the IFN/STAT1 pathway is closely associated with drug response and recurrence of breast cancer treated by chemotherapy. The aim of the current study was to elucidate the molecular mechanisms involved upstream and downstream of this pathway in order to identify distinct entities that might be manipulated to improve treatment efficacy. Four breast cancer cell lines (T-47D, MCF7, MDA...

HIV-1 evades immune detection by the cGAS-STING cytosolic DNA-sensing pathway during acute infection. STING is a critical mediator of type I IFN production, and STING agonists such as cGMP-AMP (cGAMP) and other cyclic dinucleotides elicit potent immune and antitumor response. In this article, we show that administration of cGAMP, delivered by an ultra-pH-sensitive nanoparticle (NP; PC7A), in hu...

BACKGROUND Bee sting therapy is increasingly used to treat patients with multiple sclerosis (MS) in the belief that it can stabilize or ameliorate the disease. However, there are no clinical studies to justify its use. METHODS In a randomized, crossover study, we assigned 26 patients with relapsing-remitting or relapsing secondary progressive MS to 24 weeks of medically supervised bee sting t...

OBJECTIVE This study was to evaluate the levels of NT-proBNP in patients with myocarditis which occurred after a scorpion sting envenomation. MATERIAL AND METHODS A total of 30 patients with scorpion sting envenomation and 21 patients with heart failure which was caused by cardiomyopathy, were prospectively studied. The data included the patient demographics, clinical features, echocardiograp...

Jellyfish have a worldwide distribution. Their stings can cause different reactions, ranging from cutaneous, localized, and self-limited to serious systemic or fatal ones, depending on the envenoming species. Several first aid treatments are used to manage such stings but few have evidence behind their use. This review of the literature describes and discusses the different related first aid an...