Isolation and Characterization of Novel Giant Stenotrophomonas maltophilia Phage SMA5 Hsiao-Chuan Chang, Chiy-Rong Chen, Juey-Wen Lin, Gwan-Han Shen, Kai-Ming Chang, Yi-Hsiung Tseng,* and Shu-Fen Weng* Institute of Molecular Biology and Institute of Biochemistry, National Chung Hsing University, Pulmonary and Critical Care Medicine Section, Taichung Veterans General Hospital, and Center for Res...

Patients with cancer are at high risk for infections caused by antibiotic resistant gram-negative bacteria. In this review, we summarize trends among the major pathogens and clinical syndromes associated with antibiotic resistant gram-negative bacterial infection in patients with malignancy, with special attention to carbapenem and expanded-spectrum β-lactam resistance in Escherichia coli, Kleb...

INTRODUCTION The aim of this study was to determine incidence, risk factors, and impact on outcome of intensive care unit (ICU)-acquired Stenotrophomonas maltophilia. METHODS This prospective observational case-control study, which was a part of a cohort study, was conducted in a 30-bed ICU during a three year period. All immunocompetent patients hospitalised >48 hours were eligible. Patients...

The aac(6')-Iz gene of Stenotrophomonas maltophilia BM2690 encoding an aminoglycoside 6'-N-acetyltransferase was characterized. The gene was identified as a coding sequence of 462 bp corresponding to a protein with a calculated mass of 16,506 Da, a value in good agreement with that of ca. 16,000 found by in vitro coupled transcription-translation. Analysis of the deduced amino acid sequence ind...

The present study was carried out to understand the adaptive strategies developed by Stenotrophomonas maltophilia for chronic colonization of the cystic fibrosis (CF) lung. For this purpose, 13 temporally isolated strains from a single CF patient chronically infected over a 10-year period were systematically characterized for growth rate, biofilm formation, motility, mutation frequencies, antib...

INTRODUCTION Stenotrophomonas maltophilia infections have recently increased in importance in China, particularly in intensive care units (ICUs). The aim of this study was to investigate the clinical characteristics and risk factors of S. maltophilia infection in ICU of a hospital in northwest China. METHODOLOGY The characteristics and outcomes of patients with any type of S. maltophilia infe...

Stenotrophomonas maltophilia is an important pathogen in healthcare-associated infections. S. maltophilia may contain Smqnr, a quinolone resistance gene encoding the pentapeptide repeat protein, which confers low-level quinolone resistance upon expression in a heterologous host. We investigated the prevalence of Smqnr and plasmid-mediated quinolone resistance (PMQR) determinants in S. maltophil...

Background Stenotrophomonas maltophilia is a pathogen commonly associated with respiratory infection. However, the characteristics of pneumonia caused by S. remain unknown. Aim To evaluate and risk factors for pneumonia. Methods A retrospective evaluation was undertaken 2002 patients sputum cultures positive between January 2010 December 2019. Cases were excluded based on clinical information l...

Peritonitis is a common and potentially serious complication of peritoneal dialysis (PD). Common organisms include Staphylococcus Aureus, enterococci, coagulase-negative staphylococcus. However, Stenotrophomonas maltophilia (S. maltophilia) an uncommon cause PD-related infection. We describe series three cases S. PD infection (two peritonitis one case exit-site infection) that were identified o...

BACKGROUND Stenotrophomonas maltophilia causes serious infections in immunocompromised hosts. Here, we analyzed the clinical characteristics of S. maltophilia bloodstream infection (BSI) in patients with hematologic malignancies and evaluated in vitro synergistic effects of antimicrobial combinations. METHODS We retrospectively reviewed all consecutive episodes of S. maltophilia BSIs in adult...