signaling in pluripotent stem cells is a complex and dynamic process involving multiple mediators, finely tuned to balancing pluripotency and differentiation states. characterizing and modifying the necessary signaling pathways to attain desired cell types is required for stem-cell applications in various fields of regenerative medicine. these signals may help enhance the differentiation potent...

background: bone marrow has recently been recognized as a novel source of stem cells for the treatment of wide range of diseases. a number of studies on murine bone marrow have shown a homogenous population of rare stage-specific embryonic antigen 1 (ssea-1) positive cells that express markers of pluripotent stem cells. this study focuses on ssea-1 positive cells isolated from murine bone marro...

conclusions this review was to focus on the roles of ascs in different applications and also provide the researcher general information about the history and current applications of ascs. we found that the ascs have a potential role to be used for the treatment of different sorts of disorders, with the less side effects and is also a new approach toward new remedies. context after about 40 year...

background: marrow-derived mesenchymal stem cells (mscs) have been heralded as a source of great promise for the regeneration of the infarcted heart. there are no clear data as to whether or not in vitro differentiation of mscs into major myocardial cells can increase the beneficial effects of mscs. the aim of this study was to address this issue. methods: to induce mscs to transdifferentiate i...

background: stem-cell technology has been advocated as a potentially curative option for treatment of both type 1 and type 2 diabetes. in the current study, we aimed to assess the effectiveness of allotransplantation of fetal liver-derived cells for treatment of patients with type 1 diabetes. methods: for the purpose of the current study, 72 patients with recently diagnosed type 1 dm were recru...

background: although the pathogenesis of diabetes type 1 (t1d) is not fully elucidated. different clusters of lymphocytes such as cd4+ and cd8+ t cells are involved in it. moreover, the mechanism of how stem-cell therapy results in significant therapeutic outcomes in diabetes remains obscure. in the current study, we aimed to analyze lymphocyte subsets in patients with t1d before and after trea...

background: today, hematopoietic stem cells transplantation (hsct) has been accepted as a therapeutic approach and is widely applied in many patients with disorders of hematopoietic systems or patients with malignancies. concomitant use of this therapeutic approach with long term chemotherapeutic procedures and hospitalization requires special care. this study was conducted to examine basic nee...

this study discusses the effect of complexes of chitosan grafted polyethylenimine(ch-pei) with plasmid dna on viability of mesenchymal stem cells(mscs) derived from human marrow. ch-pei/pdna nanoparticles were synthesized through the complex coacervation method using pires plasmid containing green fluorescent protein (gfp) gene. to confirm the complexation, samples were run through an agarose g...

multiple sclerosis (ms) is an autoimmune disease, which is characterized by demyelination and neuroinflammation. extracellular matrix (ecm) have important role in the central nervous system (cns). alterations are happening to the ecm after the cns disorder like ms, alzheimer and other neural injury. tenasin-c (tnc) is a glycoprotein that is highly expressed in inflammatory conditions of the cns...