For many years it has been assumed tacitly that lipids and proteins are retained during the process of fixation by various heavy metals. Experimental evidence documenting this assumption has been sparse but recent studies by Korn and Weisman (1) show that varying amounts of neutral lipids and phospholipids are lost from amebae during fixation for electron microscopy. Stein and Stein 1 also have...

We study a general algorithm to improve accuracy in cluster analysis that employs the James-Stein shrinkage effect in k-means clustering. We shrink the centroids of clusters toward the overall mean of all data using a James-Stein-type adjustment, and then the James-Stein shrinkage estimators act as the new centroids in the next clustering iteration until convergence. We compare the shrinkage re...

5. GUTFREUND, El., Trans. Faraday Sot., 61, 441 (1955). 6. WALBFI, K. A., KAUFFMAN, D. L., SAMPATH KUMAR, K. S. V., AND NEURATE, H., Proc. Natl. Ad. Sci. U. S., 51, 301 (1964). 7. WALSH, K. A., AND NEURATH, H., Proc. Nail. Acad. Sci. U. S., 52, 884 (1964). 8. MARE&GUIA, M., AND SHAW, E., Federation Proc., 22, 528 (1963). 9. CRESTFIELD, A. M., STEIN, W. H., AND MOORE, S., J. Bid. Chem., 238, 241...

We consider the nonparametric functional estimation of the drift of a Gaussian process via minimax and Bayes estimators. In this context, we construct superefficient estimators of Stein type for such drifts using the Malliavin integration by parts formula and superharmonic functionals on Gaussian space. Our results are illustrated by numerical simulations and extend the construction of James–St...

We explore the extension of James-Stein type estimators in a direction that enables them to preserve their superiority when the sample size goes to infinity. Instead of shrinking a base estimator towards a fixed point, we shrink it towards a data-dependent point. We provide an analytic expression for the asymptotic risk and bias of James-Stein type estimators shrunk towards a data-dependent poi...

Reseña de "Authorizing Superhero Comics. On the Evolution of a Popular Serial Genre" Daniel Stein.

This article explores the ‘symbolic reality’ of two twentieth century theologians inspired by works Dionysius Areopagite: Edith Stein/Teresia Benedicta a Cruce ocd (1891-1942) and Marie-Dominique Chenu op (1895-1990). To illustrate their arguments about role symbolic in Christian life, author takes as his text great narrative poem English Jesuit Gerard Manley Hopkins (1844-889), The Wreck Deuts...

Acquisition of data: Silverstein, Feinberg, Sauder, Egbert, and Stein. Analysis and interpretation of data: SilversteinandFeinberg. Drafting of the manuscript: Silverstein and Sauder. Critical revision of the manuscript for important intellectual content: Silverstein, Feinberg, Egbert, and Stein. Statistical analysis: Silverstein. Obtained funding: Silverstein and Feinberg. Administrative, tech...

Standard Markov chain Monte Carlo diagnostics, like effective sample size, are ineffective for biased sampling procedures that sacrifice asymptotic correctness for computational speed. Recent work addresses this issue for a class of strongly log-concave target distributions by constructing a computable discrepancy measure based on Stein’s method that provably determines convergence to the targe...

Variance-Gamma distributions are widely used in financial modelling and contain as special cases the normal, Gamma and Laplace distributions. In this paper we extend Stein’s method to this class of distributions. In particular, we obtain a Stein equation and smoothness estimates for its solution. This Stein equation has the attractive property of reducing to the known normal and Gamma Stein equ...