Lipoprotein lipase (LPL) is a key enzyme for fatty acid and lipoprotein metabolism in muscle. However, the effect of aging on LPL regulation in skeletal muscle is unknown. We report the effect of aging on LPL regulation in the soleus (red oxidative postural) muscle and the tibialis anterior (white glycolytic non-weight-bearing) muscle in 4- and 24-mo-old Fischer 344 rats and 18- and 31-mo-old F...

Chronological aging has been studied extensively in laboratory yeast by culturing cells into stationary phase in synthetic complete medium with 2% glucose as the carbon source. During this process, acidification of the culture medium occurs due to secretion of organic acids, including acetic acid, which limits survival of yeast cells. Dietary restriction or buffering the medium to pH 6 prevents...

Microarrays were utilized to determine gene expression of vascular endothelial cells (ECs) subjected to mechanical stretch for insight into the role of strain in vascular pathophysiology. Over 4,000 genes were screened for expression changes resulting from cyclic strain (10%, 1 Hz) of human umbilical vein ECs for 6 and 24 h. Comparison of t-statistics and adjusted P values identified genes havi...

OBJECTIVE Pfirrmann disc grade is a useful scoring tool for evaluating disc degeneration, but normal values according to aging process has not been elucidated. This study was conducted to identify the prevalence and pattern of whole spine disc degeneration according to ages and gender differences. METHODS Total 653 patients (336 male and 317 female patients, 48.1±58.7 years old) who took whol...

ABSTRACT- Bruising degrades the quality of fresh apple fruits. Reducing bruise damage is of utmost importance in designing and developing processing equipments. The main objective of the present study was to introduce an analytical method to predict the allowable static load applicable to apple fruits. To predict the strain energy absorbed by the fruit, a point load was applied on the solid sph...

The cracking resistance of asphalt mixture is a non-negligible issue. However, the evolution law, motivated by two factors (thermos-oxidative aging degree and test temperature), not yet well understood. aim this investigation to gain more insight into effect thermos-oxidative temperature on mixture. Asphalt (AC-13) stone mastic (SMA-13) were selected exposed different thermo-oxidative degrees (...

The present work deals with revealing the fatigue and dwell-fatigue behavior correlated damage mechanisms of Fe–Mn–Al–C lightweight steel. Surprisingly, alteration in loading mode from monotonic to cyclic induces reversible dislocation movement facilitates occurrence dynamic strain aging. Additionally, applying dwell time by an acceleration aging intensified stress asymmetry during fatigue. has...