The role of taxanes in the treatment of breast cancer is becoming increasingly important. In clinical practice, the taxanes are now standard therapy in both early-stage and metastatic breast cancer. Since the 1990s, multiple randomized clinical trials have been evaluating the efficacy of taxanes in the treatment of metastatic breast cancer. These trials have included treatment with taxanes alon...

The purpose of the current research is to provide a performance appraisal system capable of considering the value chain network structure of research and development (R&D) projects for Complex products and systems (CoPS) under uncertainty of data. Therefore, in order to achieve this goal, a network data envelopment analysis (NDEA) approach and the possibilistic programming to provide a new fuzz...

We take as our starting point the state of geographic information systems (GIS) and spatial data analysis 50 years ago when regional science emerged as a new field of enquiry. In the late 1950s and 1960s advances in computing technology were making possible forms of automated cartography that in due course would lead to the development of GIS. Although few would have imagined at that time that ...

This thesis explores design options for naval vessels and provides a framework for analyzing their benefit to the Navy. Future demands on Navy warships, such as new or changing missions and capabilities, are unknowns at the time of the ship's design. Therefore, ships often require costly engineering changes throughout their service life. These are expensive both fiscally because the Navy pays f...

Lack of security is one of the most widespread problems affecting information systems. Security breaches at companies are reported almost everyday and users of computer systems are busy updating security of their computer system against vulnerabilities. While some of these problems are caused by human errors and faults of physical devices but the majority of them are due to the defects in softw...

Prevention of osteoporotic fractures requires accurate methods to detect the increase in bone fragility at an early disease stage as well as effective therapies to reduce the risk of bone fractures. Presently the prediction of the patient-specific bone fracture risk is primarily based on bone density, since this is the only parameter which can routinely be measured in vivo. However, these predi...

Parametric design for complex engineering systems at the early stage involves identifying feasible candidates for detailed stages that satisfy multiple performance requirements at different levels. Conventional methods, using system analysis through “trial-and-error” iterations to pursue optimal solutions, are not robust and inflexible for further design and performance changes. In this paper, ...