To date, no effective cure has been found for high grade malignant glioma (HGG), current median survival for HGG patients under treatment ranging from 18 months (grade IV) to 5 years (grade III). Recently, T cell therapy for HGG has been suggested as a promising avenue for treating such resistant tumors, but clinical outcome has not been conclusive. For studying this new therapy option, a mathe...

The measurement of the fractional breakdown rate (FBR) of muscle proteins during physiological non-steady state of amino acids (AAs) presents some challenges. Therefore, the goal of the present experiment was to modify the bolus stable isotope tracer injection approach to determine both fractional synthesis rate (FSR) and FBR of leg muscle protein during a physiological non-steady state of AAs....

The effects of steady-state faldaprevir on the safety, pharmacokinetics, and pharmacodynamics of steady-state methadone and buprenorphine-naloxone were assessed in 34 healthy male and female subjects receiving stable addiction management therapy. Subjects continued receiving a stable oral dose of either methadone (up to a maximum dose of 180 mg per day) or buprenorphine-naloxone (up to a maximu...

In this article some of the hydrodynamical (HD) aspects of steady shocks as described by the steady-state shock model are reviewed and discussed. It is found that, at least in some of the contexts in which the steady-state model is used, the steady-state assumption cannot be satisfied. Moreover, the main result of the present work is that even if the assumptions on steadiness and on the geometr...

-The paper investigates the transient behaviour and stability of a system consisting of two thermally conducting elastic rods in contact on their end faces, the other ends of the rods being built-in to two rigid walls which are maintained at different temperatures. It is assumed that there is a thermal resistance at the interface between the rods which is a known function of contact pressure or...