miRNAs play important roles during mammalian spermatogenesis. However, the function of most miRNAs in spermatogenesis and the underlying mechanisms remain unknown. Here, we report that miR-202 is highly expressed in mouse spermatogonial stem cells (SSCs), and is oppositely regulated by Glial cell-Derived Neurotrophic Factor (GDNF) and retinoic acid (RA), two key factors for SSC self-renewal and...

Spermatogonial stem cells (SSCs) are the foundation of spermatogenesis and are located in a highly dynamic microenvironment called "niche" that influences all aspects of stem cell function, including homing, self-renewal and differentiation. Several studies have recently identified specific proteins that regulate the fate of SSCs. These studies also aimed at identifying surface markers that wou...

Male mammals produce sperm for most of postnatal life and therefore require a robust germ line stem cell system, with precise balance between self-renewal and differentiation. Prior work established doublesex- and mab-3-related transcription factor 1 (Dmrt1) as a conserved transcriptional regulator of male sexual differentiation. Here we investigate the role of Dmrt1 in mouse spermatogonial ste...

Skeletal stem cells (SSCs) reside in the postnatal bonemarrowand give rise to cartilage, bone, hematopoiesis-supportive stroma and marrow adipocytes indefined in vivoassays.These lineagesemerge inaspecific sequence during embryonic development and post natal growth, and together comprise a continuous anatomical system, the bone-bone marroworgan.SSCsconjoin skeletal andhematopoieticphysiology, a...

Although Multiple Subject Constructions in Korean have received significant attention in theoretical literature, few experimental investigations of various syntactic and semantic properties of these constructions have been conducted. In this study, we administered a Magnitude Estimation (ME) experiment in order to compare the acceptability of Multiple Subject and related Single Subject Construc...

Presents information on various USTC/SSCS Society chapters.

Introduction: Nowadays, spermatogonial stem cells (SSCs) cultivation has been used by many researchers as an effective tool for infertility treatments. Oxidative conditions can be effective on cell proliferation and differentiation of these cells. So, the aim of this study was to establish oxidative stress model for antioxidant activity of some drugs investigation during SSCs in vitro culture. ...

The IEEE Solid-State Circuits Society (SSCS) Beijing Chapter, together with the SSCS Tsinghua Student organized five International Conference (ISSCC) promotion seminars from late March to April, at University, Peking University of Technology, Institute Semiconductors, Chinese Academy Sciences, and Posts Telecommunications, respectively. participants were mainly undergraduates majoring in electr...

the complex process of spermatogenesis is regulated by various factors. studies on spermatogonial stem cells (sccs) have provided very important tool to improve herd genetic and different field. 0.2 to 0.3 percent of total cells of seminiferous tubules is consist of spermatogonial stem cells. to investigate and biomanipulation of these cells, proliferation and viability rate of cells should be ...

Human bone marrow (BM)-derived stromal cells contain a population of skeletal stem (SSCs), with the capacity to differentiate along osteogenic, adipogenic, and chondrogenic lineages, enabling their application clinical therapies. However, current methods isolate enrich SSCs from human tissues remain, at best, challenging in absence specific SSC marker. Unfortunately, none proposed markers alone...