BACKGROUND Heat shock proteins are highly conserved immunodominant antigens found in various species. Humoral immune responses to mycobacterial HSP65 and human HSP60 have been established in a number of human autoimmune diseases. OBJECTIVE To assess the prevalence of antibodies to HSP60 kDa and HSP65 kDa in patients with Sjögren's syndrome as compared to normal subjects. METHODS Thirty-seve...

OBJECTIVE To investigate eicosanoid concentrations in the saliva of patients with primary Sjögren's syndrome (SS). METHODS Whole mixed saliva of 36 subjects was assayed for eicosanoid concentrations using a radioimmunoassay. Patients with primary SS having positive lip biopsy served as the study group; their results were compared with data from patients with dry mouth and negative lip biopsy ...

OBJECTIVE To assess the health status and fatigue in sicca patients with or without Sjögren's syndrome (SS) and to test whether the immune-inflammatory activity or the extent of the disease predict fatigue in SS. METHODS The Medical Outcomes Study Short-Form General Health Survey (MOS SF-36) was used in 1 degree SS (n = 90), 2 degrees SS (n = 24), non-SS patients with sicca symptoms (n = 15) ...

beta 2 Microglobulin concentration in tear fluid was measured in 35 patients with primary Sjögren's syndrome (SS), in 28 normal control subjects matched for age and sex, and in 18 patients with arthralgias or myalgias and sicca complaints, in whom the diagnosis primary SS had been excluded. Increased beta 2 microglobulin concentrations were found in the patients with SS, but no correlation was ...

‎given a finite non-cyclic group $g$‎, ‎call $sigma(g)$ the smallest number of proper subgroups of $g$ needed to cover $g$‎. ‎lucchini and detomi conjectured that if a nonabelian group $g$ is such that $sigma(g) < sigma(g/n)$ for every non-trivial normal subgroup $n$ of $g$ then $g$ is textit{monolithic}‎, ‎meaning that it admits a unique minimal normal subgroup‎. ‎in this paper we show how thi...

As demonstrated by several studies, the pan-inhibitory peptide somatostatin (SS) is implicated in a large variety of physiological processes in the gastrointestinal tractus. SS inhibits hormonal and gastric acid secretions, and decreases gastric and intestinal motility, mesenteric blood flow and intestinal absorption. In vitro and in vivo studies showed also that the antiproliferative potency o...

Fetal frontal cortex transplants that survived 2-9 months in cavities in adult rat motor/sensory cortex were processed for vasoactive intestinal polypeptide (VIP), somatostatin 14 (SS), and neuropeptide Y (NPY) immunocytochemistry, and NADPH-diaphorase (NADPH-d) histochemistry. All transplants had surviving VIP, SS, NPY, and NADPH-d neuronal perikarya and fibers with normal adult morphology. Th...

Labial salivary gland biopsy samples were taken from 27 patients with primary Sjögren's syndrome (SS), 10 with rheumatoid arthritis (RA) and secondary SS, and four normal control subjects on two occasions at intervals of more than one year. In the former group of patients, eight of the nine initially negative analyses were positive on the second sample, whereas two of the seven patients with RA...

Recent findings that hemoglobin S gelation was greatly increased only between blood and sickling are pH-dependent and also pH 7.4 and 7.2 (cell pH 7.2 and 7.0. a shift influence oxygen affinity suggested that that strongly affects gelation). with L log the red cells containing this hemoglobin p50/ L pH -0.92 to -0.99 (normal variant might show an abnormal Bohr 0.42 to 0.46). Thus a drop in SS b...

Motivated by the problem of extending stable semantics (SS) and well-founded semantics (WFS) while avoiding their drawbacks, we propose a new simple and intuitive semantics for (normal) logic programs, called canonical Kripke model semantics. Our approach is based on formulating stability in an intuitionistic framework which helps us overcome several drawbacks. As a consequence, every normal pr...