Effective splice site selection is critically controlled by flanking splicing regulatory elements (SREs) that can enhance or repress splice site use. Although several computational algorithms currently identify a multitude of potential SRE motifs, their predictive power with respect to mutation effects is limited. Following a RESCUE-type approach, we defined a hexamer-based 'HEXplorer score' as...

We revise in this paper the Partial Enumeration (PE) method for the fast computation of a suboptimal solution to linear MPC problems. We derive novel robust exponential stability results for difference inclusions to show that the existence of a continuous Lyapunov function implies Strong Robust Exponential Stability (SRES), i.e. for any sufficiently small perturbation. Given the fact that the s...

Papers published in Hydrology and Earth System Sciences Discussions are under open-access review for the journal Hydrology and Earth System Sciences Abstract Land-use change and climate change, along with groundwater pumping are frequently indicated to be the main human-induced factors influencing the groundwater system. Up till now, research has mainly been focusing on the effect of the water ...

This study aims to assess how high-latitude vegetation may respond under various climate scenarios during the 21st century with a focus on analyzing model parameters induced uncertainty and how this uncertainty compares to the uncertainty induced by various climates. The analysis was based on a set of 10,000 Monte Carlo ensemble Lund-Potsdam-Jena (LPJ) simulations for the northern high latitude...

As climate change is projected to impose profound global variations in the freshwater resources, assessing the impacts of the former on the latter is a fundamental task for improving the water management, namely, in arid and semiarid areas, as there a plenty of in countries like Iran. Such is the objective of the present paper, where the impacts of climate change on the water availability in th...

Breast cancer is a very common diagnosis in women; approximately 30% of patients with breast cancer will develop bone metastases. In addition, breast cancer patients experience adjuvant treatment related bone loss. Bisphosphonates (BPs) are the standard of care for maintaining bone health in patients with cancer. The purpose of this paper is to review the evidence on the use of zoledronic acid ...

Translational repression of maternal mRNAs is an essential regulatory mechanism during early embryonic development. Repression of the Drosophila nanos mRNA, required for the formation of the anterior-posterior body axis, depends on the protein Smaug binding to two Smaug recognition elements (SREs) in the nanos 3' UTR. In a comprehensive mass spectrometric analysis of the SRE-dependent repressor...

Downscaled and hydrologically modeled projections from an ensemble of 16 Global Climate Models suggest that flooding may become more intense on the western slopes of the Sierra Nevada mountains, the primary source for California’s managed water system. By the end of the 21st century, all 16 climate projections for the high greenhouse-gas emission SRES A2 scenario yield larger floods with return...

We revise in this paper the Partial Enumeration (PE) method for the fast computation of a suboptimal solution to linear MPC problems. We derive novel robust exponential stability results for difference inclusions to show that the existence of a continuous Lyapunov function implies Strong Robust Exponential Stability (SRES), i.e. for any sufficiently small perturbation. Given the fact that the s...

This paper presents a global scale assessment of the impact of climate change on water scarcity. Patterns of climate change from 21 Global Climate Models (GCMs) under four SRES scenarios are applied to a global hydrological model to estimate water resources across 1339 watersheds. The Water Crowding Index (WCI) and the Water Stress Index (WSI) are used to calculate exposure to increases and dec...