Cellulose acetate (CA)/strontium phosphate (SrP) hybrid coating has been proposed as an effective strategy to build up novel bone-like structures for bone healing since CA is soluble in most organic solvents. Strontium (Sr2+) reported a potential agent treat degenerative diseases due its osteopromotive and antibacterial effects. Herein, bioactive composite SrP-based coatings (CASrP) were succes...

SUPPORTING INFORMATION S1. Method details for QM/MM S2. Spin densities for Ca and Sr QM/MM models in the S1, S0, S-1, and S-2 states S3. Interatomic distances for OEC atoms in QM/MM models S4. Structural changes due to Ca/Sr substitution in QM/MM models of the S1, S0, S-1, and S-2 states S5. EXAFS simulations S6. RMSDs of QM/MM models against XRD coordinates S7. QM/MM optimized coordinates QM/M...

Two recombinant aequorin isoforms with different Ca2+ affinities, specifically targeted to the endoplasmic reticulum (ER), were used in parallel to investigate free Ca2+ homeostasis in the lumen of this organelle. Here we show that, although identically and homogeneously distributed in the ER system, as revealed by both immunocytochemical and functional evidence, the two aequorins measured appa...

Coordination compounds with mixed ligands were synthesized 2A group (Mg2+, Ca2+, Ba2+, Sr2+) alkaline earth metal cations of coumarilic acid and nicotinamide ligands. Afterward, the structural properties these new molecules investigated by melting point, elemental analysis, infrared spectroscopy, thermal analysis (TGA / DTA) curves, powder X-ray diffraction (P-XRD) spectroscopy. It has been sug...

BackgroundShorter but effective tuberculosis treatment regimens would be of value to the community. High-dose rifampicin has been associated with more rapid and secure lung sterilization may enable shorter regimens.MethodsWe randomly assigned adults who were given a diagnosis rifampicin-susceptible pulmonary 6-month control regimen, similar 4-month regimen at 1200 mg/d (study 1 [SR1]), or 1800 ...

The photoluminescence properties of Eu2+-activated α’-Sr2SiO4 and α’-Ba2SiO4 with a high Eu2+ concentration were investigated. In the case of Sr2−xEuxSiO4, emission was shifted from 585 to 611 nm with increasing the total Eu2+ concentration (x) from 0.1 to 0.8. This trend was similar to that in Ba2−xEuxSiO4, where the emission was shifted from 513 to 545 nm. The large redshifts in both the exci...

Fusion of plasma membranes isolated from myoblasts grown in culture has been investigated. 1. Membrane fusion was specifically dependent of Ca2+ at physiological concentrations. However, at higher concentrations of cations, fusion could be triggered not only by Ca2+, but by Mg2+ and Sr2+ as well. 2. The amount of fusion was directly proportional to temperature. 3. Fusion was found to depend on ...

(3-Bungarotoxin ((3-BuTX) induces twitching of innervated frog muscle and subsequently blocks transm itter release from motor nerve endings. These actions of P-BuTX are prevented if the nerve-muscle junctions are pretreated with a low concentration of phospholipase A2 from bee venom. When the Ca2+ in the external fluid is replaced by Sr2+, the phospho­ lipase activity of P-BuTX is negligible an...