Electronic Health Record (EHR) systems are becoming highly prevalent today and have the potential to add to the success of spontaneous reporting systems for post marketing surveillance of drugs. EHR systems broadly contain two forms of information viz. coded (structured) information and unstructured text. Researchers have shown that the textual data have much more utility for cohort building th...

Adverse drug reactions (ADRs) till date are still considered as one of the main problems therapy. Pharmacovigilance is monitoring safety by means spontaneous adverse-effect reporting systems, case control and cohort studies.
 This study evaluated levels awareness knowledge pharmacovigilance (i.e., ADR reporting) amongst final year students Rivers State College Health Science Technology, Po...

We read with interest the study of Andraweera et al., published recently in Acta Obstetricia et Gynecologica Scandinavica [1], reporting a strong association between maternal FTO (rs9939609) genotype and the risk of miscarriage and recurrent pregnancy loss. Inspired by the report, we attempted to test a related hypothesis that the FTO polymorphism is associated with spontaneous abortions when t...

Ibuprofen was the first member of Propionic acid derivatives introduced in 1969. It is a popular domestic and over the counter analgesic and antipyretic for adults and children. Ibuprofen has been rated as the safest conventional NSAID by spontaneous adverse drug reaction reporting systems in the UK. This article summarizes the main pharmacological effects, therapeutical applications and advers...

INTRODUCTION Pneumothorax is either primary or secondary. Secondary pneumothorax is usually due to trauma, including various non-pharmacologic iatrogenic triggers. Although not normally thought of as an adverse drug event (ADE) secondary pneumothorax is associated with numerous drugs, though it is often difficult to determine whether this association is causal in nature, or reflects an epipheno...

Objective We aimed at testing if a correlation between adverse drug reactions relative risks estimated from meta-analyses and disproportionality analyses calculated pharmacovigilance spontaneous reporting systems databases exist, methodological choices modify this correlation. Study design extracted (ADR) odds ratios (ORs) used as reference corresponding Reporting Odds Ratios (RORs) the WHO dat...

background: fatalism, an obstacle to the adoption of safe behaviors, describes the belief that injuries are unavoidable and occur due to haphazard or fate. the present study examined degree of fatalism related to injuries reporting rate and its dimensions among workers’ isfahan steel company. methods: a self-administered anonymous was distributed to 250 workers. the survey included demographic ...

abdominal wall endometriosis, the commonest type of extra-pelvic endometriosis, may rarely develop spontaneously in the absence of prior surgical scar. we aim to report 3 cases with this unique characteristic, two of them with a diagnosis of unusual development of umbilical endometriosis and one with inguinal endometriosis, from the perspective of a general surgeon. because of the potential pit...

Abstract Background Immune checkpoint inhibitors-induced myocarditis presents unique clinical challenges. Here, we assessed post-marketing safety of cytotoxic T-lymphocyte-associated protein-4 (CTLA-4), programmed cell death-1 (PD-1), and death-ligand 1 (PD-L1) inhibitors by mining the real-world data reported in two international pharmacovigilance databases. Methods We analyzed immune (ICIs)-a...