To the Editor: Melanoma on chronically sun-damaged skin (MSDS) is challenging to detect.1Sanchez M.I. Rabinovitz H.S. Oliverio M.C. Elgart G.W. Grichnik J.M. Confocal microscopy of dermoscopic diagnoses.Arch Dermatol. 2012; 148: 1224Crossref PubMed Scopus (1) Google Scholar Reflectance confocal (RCM) increases diagnostic accuracy but relies upon interpretation 2-dimensional (2D) horizontal sect...

Pancreatic ductal adenocarcinoma, which accounts for the majority of pancreatic cancers, is a lethal disease with few therapeutic options. Genomic profiling of pancreatic ductal adenocarcinoma has identified a complex and heterogeneous landscape. Understanding the molecular characteristics of pancreatic ductal adenocarcinoma will facilitate the identification of potential therapeutic strategies...

INTRODUCTION Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the digestive tract. There is an increasing number of literature reports on synchronous occurrence of gastrointestinal stromal tumors and another malignancy of distinct etiology and evolution. The most reported cases include gastric synchronous occurrence of gastrointestinal stromal tumors and adenocar...

BACKGROUND It has long been recognized that bronchial schwannomas are extremely rare. As such, diagnosing tumors in this extraordinary location can sometimes be problematic. METHODS We reviewed seven cases of bronchoscopically or surgically resected endobronchial schwannomas and evaluated their clinical and pathologic features. RESULTS The present study included five female and two male pat...

Abstract Phyllodes tumors (PT) are rare fibroepithelial lesions of the breast that commonly present as rapidly enlarging, palpable masses. may be classified benign, borderline, or malignant on basis histopathologic analysis. Although PT cannot distinguished from benign imaging findings alone, studies suggest tend to larger and irregular in shape, they less likely have circumscribed margins. If ...

background: gastrointestinal stromal tumors (gists) constitute the majority of gastrointestinal mesenchymal tumors. they usually express a proto-oncogen protein called cd117 detected by immunohistochemistry. this study investigated the differentiation of gists as well as the risk of aggressive behaviors in gists from surgically-treated patients in university affiliated hospitals.   methods: the...

Congenital-infantile fibrosarcoma (CIFS) is a relatively indolent sarcoma that should be distinguished from more aggressive spindle cell sarcomas of childhood. CIFSs have been found to have a novel recurrent reciprocal translocation t(12;15)(p13;q25) resulting in the gene fusion ETV6-NTRK3 (ETS variant gene 6; neurotrophic tyrosine kinase receptor type 3). We studied immunohistochemical express...

background and aims. mast cells are one of the characteristic factors in angiogenesis, growth, and metastatic spread of tumors. the distribution and significance of mast cells in many tumors have been demonstrated. however, few studies have evaluated mast cell infiltration in salivary gland tumors. in this study, mast cell counts were evaluated in benign and malignant salivary gland tumors. mat...

Stem cells possess the properties of self-renewal and differentiation, and mainly rely on two strategies for division, including symmetric and asymmetric cell divisions. In this review, we summarize the latest progress on asymmetric cell divisions in Drosophila melanogaster neuroblasts (NBs), which focus on the establishment of cell polarity, mitotic spindle orientation, the asymmetric segregat...

A 65-year-old housewife presented with a diagnosis of malignant spindle cell tumor of the bladder which had been diagnosed by work up for chance hematuria. Urine cytology revealed a small number of squamous epithelial cells showing dyskeratosis but no spindle cells. Computed tomography and magnetic resonance images showed a markedly enhanced mass, 4 cm in diameter, on the anterior wall of the u...