Proper assembly of the spindle apparatus is crucially important for faithful chromosome segregation during anaphase. Thanks to the effort over the last decades, we have very detailed information about many events leading to spindle assembly and chromosome segregation, however we still do not understand certain aspects, including, for example, spindle length control. When tight regulation of spi...

The mitotic spindle checkpoint represents a signal transduction pathway that prevents the onset of anaphase until all chromosomes are properly aligned on a metaphase plate. Partial inactivation of this checkpoint allows premature separation of sister chromatids and results in aneuploidy, which might contribute to tumorigenesis. Unlike other cell cycle checkpoints, the spindle checkpoint is esse...

Cortical cell polarity controls mitotic spindle orientation in many cell types. In this issue of Cell, it is turned around and shown that the transfer of polarity information between the cortex and the spindle is not just one way. In Drosophila neuroblasts, the spindle also has polarizing activity on the cortex.

conclusions the clinical features are effective indicators for distinguishing ihh from hbl, and the spectral doppler may be a useful adjunct parameter for differential diagnosis. objectives to study the clinical manifestations and the ultrasound features of the pediatric patients for distinguishing ihh from hbl. patients and methods between 2002 and 2012, thirteen children with ihh and 38 child...

A seronegative middle-aged Saudi man with history of Kaposi sarcoma, presents a recurrent dusky brown nodular lesion on the thigh. Histopathologic examination showed spindle cell intervening slit-like vascular spaces that are immunoreactive to HHV-8.

the suppression of the regenerative chatter phenomenon in turning process via the variation of the frequency and amplitude of the spindle motor excitation is carried out in this research. a programmable inverter is employed for variable periodic excitation of the spindle motor. a set of turning experiments is designed and performed on a number of conical work pieces both in constant spindle spe...

Retiform hemangioendothelioma (RH) is a rare low-grade variant of angiosarcoma mostly reported on dermis or subcutaneously. A 30-year-old woman suffering from dry cough, dyspnea and pleural effusion has been described. Distinctive symptoms and lesions on high resolution computed tomography (HRCT) scan and common histological, immunological feature are discussed. Diagnosis was made by thoracosco...

The mitotic spindle is a cellular structure that guides proper chromosome segregation to daughter cells, thus ensuring genomic stability during cell proliferation. The mitotic spindle is made of microtubules, polymers of alpha and beta tubulin, and it is highly dynamic during the cell cycle, indeed it is build de novo and it is destroyed at each cell division. The spindle form, position and fun...

Development and homeostasis require repeated symmetric cell divisions, which in turn depend on a centered mitotic spindle. In this issue, Kiyomitsu and Cheeseman uncover two mechanisms that ensure correct spindle positioning in anaphase: cortical dynein for pulling the spindle to the cell center and asymmetric membrane elongation that adjusts the position of the cell center to the cleavage plane.

During cell division, a microtubule-based mitotic spindle mediates the faithful segregation of duplicated chromosomes into daughter cells. Proper length control of the metaphase mitotic spindle is critical to this process and is thought to be achieved through a mechanism in which spindle pole separation forces from plus-end-directed motors are balanced by forces from minus-end-directed motors t...