objective: various approaches have been offered for resolution of pain resulting from spinal cord injuries. one approach is the use of herbal and natural products. in the present research, as a preliminary study, we investigate the effect of crocin on chronic pain induced by contusion in the rat spinal cord (sci). methods: we randomly divided female wistar rats into five groups. groups i and ii...

OBJECTIVES Iatrogenic spinal cord injuries (SCIs) caused by invasive procedures or surgical interventions have previously been reported as case studies. The primary objective of this study was to investigate and analyze the incidence, etiology, and prognosis of iatrogenic SCI in Western Norway. METHODS Medical records of all 183 patients admitted to the SCU between 01.01.2004 and 31.12.2013 w...

A recent article by Dr Robert Heimburger in the Journal was titled, “Is there hope for return of function in lower extremities paralyzed by spinal cord injury?” This question can be answered by showing that innovative attempts are currently being pursued in the hope, as requested by Dr Heimburger, to improve the neurologic results of patients who tragically sustain a spinal cord injury (SCI). D...

Spinal cord injury (SCI) is one of the most severe traumatic injuries that results in dysfunction of limbs and trunk below the damaged section. Recent studies have shown that gastrodin (GAS) could improve the recovery of SCI. In the current study, we aimed to examine the possible mechanism underlying the effect of GAS on recovery of SCI in rats. In rats with SCI, GAS improved locomotor function...

Spinal cord injury (SCI) is a devastating neurologic disorder that often inflicts neuropathic pain, which further impacts negatively on the patient's quality of life. Endothelin peptides, which exert their effects via endothelin A (ETAR) and endothelin B (ETBR) receptors, can contribute to sensory changes associated with inflammatory and neuropathic pain, but their role in nociception following...

Objective(s) Recent studies revealed the neuroprotective effects of epigallocatechin gallate (EGCG) on a variety of neural injury .The purpose of this study was to determine the effects of EGCG on the tissue lipid peroxidation after spinal cord injury (SCI). Materials and Methods Rats were randomly divided into four groups of 7 rats each as follows: sham-operated group, trauma group, and EGC...

Background: Neutrophil infiltration plays an important role in inflammatory reactions following spinal cord injury (SCI) and these cells cause substantial secondary tissue damage. The purpose of this study was to determine the effect of oleuropein (OE) on myeloperoxidase (MPO) activity as an index of neutrophil infiltration. Methods: Rats were randomly divided into four groups of 7 rats each as...

Background: Spinal cord injury (SCI) refers to spinal cord damage arising from trauma, disease or degeneration. At present, there is still no treatment for any paraplegia resulting from SCI. We have previously shown that very low intensity, low frequency, electromagnetic field treatment (VLIFE) promotes neuronal plasticity after stroke and as a result, improves clinical recovery. Objective: In ...

Spinal Cord Injury (SCI) affects approximately 10,000 people per year in North America. Over the last twenty years, significant advances have been made in the understanding the pathophysiology of traumatic spinal cord injuries. In addition there have been concurrent advances in embryonic stem cells (ESCs) and the various pathways of their differentiation into neural stem cells (NSCs) and progen...

The spinal vascular system is the conduit through which nutrition, cells and drugs access the parenchyma of the spinal cord (SC). This system is severely damaged as a principal consequence of the spinal cord injury (SCI). The initial vascular damage plays a critical role in establishing the course of the well-established postinjury cascade including compromised blood spinal cord permeability, h...