Background: The incidence of concurrent traumatic brain injury (TBI) and cervical spine (c-spine) is relatively high, with a variety risk factors. Objectives: purpose this study was to determine the related factors associated combined cranial c-spine in TBI patients by assessing their demographics clinical profiles. Method: A retrospective attending Trauma Centre at Inkosi Albert Luthuli Hospit...

Cellular transplantation strategies utilizing intraspinal injection of mesenchymal progenitor cells (MPCs) have been reported as beneficial for spinal cord injuries. However, intraspinal injection is not only technically challenging, but requires invasive surgical procedures for patients. Therefore, we investigated the feasibility and potential benefits of noninvasive intravenous injection of M...

DESCRIPTION A 57-year-old man was admitted to the emergency department with blunt thoracic and abdominal trauma after being hit by a tree. CT of the thorax and abdomen was performed. Abdominal CT showed a large retroperitoneal haematoma secondary to an injury of celiac trunk; thoracic CT showed a right haemo-pneumothorax, a pneumomediastinum, a large basal lung contusion, a small dorsal right s...

Serotonin in the spinal cord acutely modulates nociceptive transmission and motor reflexes and may also assist functional restoration after spinal cord injury (SCI). It is released there mainly by descending axons of the medulla's nucleus raphe magnus (NRM). We examined whether mechanical allodynia (cutaneous hypersensitivity) after incomplete SCI is sustainably reversed by prolonged, intermitt...

Treatment with testosterone is neuroprotective/neurotherapeutic after a variety of motoneuron injuries. Here we assessed whether testosterone might have similar beneficial effects after spinal cord injury (SCI). Young adult female rats received either sham or T9 spinal cord contusion injuries and were implanted with blank or testosterone-filled Silastic capsules. Four weeks later, motoneurons i...

KINEMATIC ANALYSIS OF TREADMILL WALKING IN NORMAL AND CONTUSED MICE USING THE TREADSCAN® SYSTEM Jason Beare July 18,2007 Activity-based rehabilitation is important for clinically treating spinal cord injury (SCI). Advances in SCI research are dependent on quality animal models, which rely on our ability to detect functional differences in animals following injury. The purpose of this study is t...

Transplantation of human fetal neural stem cells (hNSCs) previously demonstrated significant functional recovery after spinal cord contusion in rats. Other studies indicated that human mesenchymal stem cells (hMSCs) can home to areas of damage and cross the blood-brain barrier. The purpose of this article is to determine if combined administration of mesenchymal stem cells and neuronal stem cel...

As one of trials on neuroprotection after spinal cord injury, we used pregabalin. After spinal cord injury (SCI) in rats using contusion model, we observed the effect of pregabalin compared to that of the control and the methylprednisolone treated rats. We observed locomotor improvement of paralyzed hindlimb and body weight changes for clinical evaluation and caspase-3, bcl-2, and p38 MAPK expr...