نتایج جستجو برای: sperm protein

تعداد نتایج: 1266734  

2012
Madhura Kulkarni Diane C. Shakes Katie Guevel Harold E. Smith

The sperm/oocyte decision in the hermaphrodite germline of Caenorhabditis elegans provides a powerful model for the characterization of stem cell fate specification and differentiation. The germline sex determination program that governs gamete fate has been well studied, but direct mediators of cell-type-specific transcription are largely unknown. We report the identification of spe-44 as a cr...

Journal: :Physiological reviews 2016
Karl Swann F Anthony Lai

The most fundamental unresolved issue of fertilization is to define how the sperm activates the egg to begin embryo development. Egg activation at fertilization in all species thus far examined is caused by some form of transient increase in the cytoplasmic free Ca(2+) concentration. What has not been clear, however, is precisely how the sperm triggers the large changes in Ca(2+) observed withi...

Journal: :Reproduction 2005
A Cesari M R Katunar M A Monclus A Vincenti J C de Rosas M W Fornés

Bovine sperm protease, 66 kDa (BSp66) is a serine protease previously characterized in bovine spermatozoa. Like other proteases, it may be present in sperm from other mammalian species different from bovine, playing a role in the fertilization process. In this study, we looked for BSp66 in hamster spermatozoa using heterologous antibodies against bovine BSp66. An immunoreactive protein was dete...

Journal: :Molecular human reproduction 2007
A Domagała S Pulido M Kurpisz J C Herr

Although the immunogenic properties of sperm have been explored for a few decades, none of the antigens studied so far appears to be an effective target, to inhibit the fertilization process or shown the full spectrum of sperm antigenic potential. Antisperm antibodies (ASA) collected from infertile individuals and prepubertal boys with cryptorchidism together with two-dimensional (2D) electroph...

Journal: :Journal of andrology 1998
S B Purohit M Laloraya P G Kumar

The nongenomic action of progesterone (P) on capacitated sperm in mediating acrosomal exocytosis operates through transmembrane signal transduction involving increased intracellular calcium ions and modulation of protein kinases and phospholipid metabolism through a second messenger pathway. Conflicting views exist regarding the nature of the nongenomic receptor of P. It is thought to be a cell...

2014
Jinghui LIU Mohamed A. MAREY Rasoul KOWSAR Nina HAMBRUCH Takashi SHIMIZU Shingo HANEDA Motozumi MATSUI Motoki SASAKI Hiroyuki HAYAKAWA Christiane PFARRER Akio MIYAMOTO

We have previously shown that polymorphonuclear neutrophils (PMNs) are present in bovine oviduct fluid under physiological conditions, and that the oviduct provides a microenvironment that protects sperm from phagocytosis by PMNs. Alpha 1-acid glycoprotein (AGP) is a major acute-phase protein produced mainly in the liver that has immunomodulatory functions. AGP mRNA is expressed in extrahepatic...

Journal: :Journal of cell science 2007
Philip C N Chiu Man-Kin Chung Riitta Koistinen Hannu Koistinen Markku Seppala Pak-Chung Ho Ernest H Y Ng Kai-Fai Lee William S B Yeung

Fertilization depends on successful binding of the spermatozoa to the zona pellucida of the oocyte. Glycodelin-A inhibits spermatozoa-zona pellucida binding. Previous data showed that glycodelin-A receptor(s) and zona pellucida protein receptor(s) on human spermatozoa are closely related. Using a chemical cross-linking approach, the glycodelin-A-sperm receptor complex was isolated. The receptor...

Journal: :The Journal of Cell Biology 1975
P S Ecklund L Levine

Mouse sperm were labeled in vivo with [3H]arginine. The sperm were then followed autoradiographically from the time of label incorporation until after fertilization. The label was completely lost from the sperm head after fertilization, during the oocyte's second meiotic division. That the [3H]arginine was incorporated into a sperm-specific basic protein was demonstrated by fractionating acid e...

Journal: :Journal of insect physiology 2015
Susanne P A den Boer Marlene Stürup Jacobus J Boomsma Boris Baer

The eusocial ants are unique in that females (queens) acquire and store sperm on a single mating flight early in adult life. This event largely determines the size (possibly millions of workers), longevity (possibly decades) and genetic variation of the colonies that queens found, but our understanding of the fundamental biology of ejaculate production, transfer and physiological function remai...

Ali Asghar Karkhaneh, Behnam Mortazavi, Farid Heidari, Mohammad Ali Eslamizade, Najaf Allahyari Fard,

Background: Contraceptive vaccines (CVs) can be used as a valuable and alternative method for the prevention of gestation in humans and animals. These vaccines can have several targets, such as superficial sperm proteins. Vaccines based on sperm antigens are quite efficacious to create a contraceptive effect. However, multi-epitope vaccines are more effective in stimulating the immune system an...

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