نتایج جستجو برای: specifically in compound channels in compound channels

تعداد نتایج: 17019329  

Journal: :British journal of pharmacology 1999
D C Hanson A Nguyen R J Mather H Rauer K Koch L E Burgess J P Rizzi C B Donovan M J Bruns P C Canniff A C Cunningham K A Verdries E Mena J C Kath G A Gutman M D Cahalan S Grissmer K G Chandy

1. UK-78,282, a novel piperidine blocker of the T lymphocyte voltage-gated K+ channel, Kv1.3, was discovered by screening a large compound file using a high-throughput 86Rb efflux assay. This compound blocks Kv1.3 with a IC50 of approximately 200 nM and 1:1 stoichiometry. A closely related compound, CP-190,325, containing a benzyl moiety in place of the benzhydryl in UK-78,282, is significantly...

Journal: :Vision Research 2009
Jason Bell Frances Wilkinson Hugh R. Wilson Gunter Loffler David R. Badcock

Combinations of radial frequency (RF) patterns may be used to represent the contours of complex shapes. Previous work has shown that many radial frequency patterns are processed globally and multiple curvature mechanisms have been proposed to account for human performance in detecting these patterns. The current paper provides a direct test of this proposal and also, investigates how different ...

The purpose of the present research is to investigate the effective channels of the monetary transmission mechanism in Iran. To do so, we devised a New Keynesian Dynamic Stochastic General Equilibrium Model. In our model, the different types of nominal rigidities are introduced beside all the related structural equations, which are extracted and linearized around a steady state point. Furthermo...

Journal: :The international journal of neuropsychopharmacology 2011
Yan-Yu Liao Shu-Fang Teng Li-Chun Lin Sabine Kolczewski Eric P Prinssen Li-Jen Lee Ing-Kang Ho Lih-Chu Chiou

The nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor is a non-opioid branch of the opioid receptor family implicated in several neurological and psychological disorders, such as pain, anxiety, depression, involuntary movement, addiction, seizure and dementia. Heterogeneity of NOP receptors has been proposed based on the findings of splicing variants and from binding and functional studies....

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