Internal controls constitute a key concept in the auditing domain. In the audit risk assessment process, auditors evaluate a firm’s internal control system to provide reasonable assurance regarding the achievement of the entity’s objectives. The present work reflects upon the design of a domain-specific modelling language for internal controls modelling. It investigates the potentials of an ent...

Apprentices in the field of sanitation, heating and cooling face the problem, that in addition to everyday lessons they have to be at the customer’s location to help the craftsmen accomplishing their orders. A proper exam preparation is thus not given as they have to study during idle times or after work. This frequently decreases also the motivation to learn. To support their studies, we have ...

Software development processes are collaborative in nature. Neglecting the key role of end-users leads to software that does not satisfy their needs. This collaboration becomes specially important when creating Domain-Specific Modeling Languages (DSMLs), which are (modeling) languages specifically designed to carry out the tasks of a particular domain. While end-users are the experts of the dom...

Multi-level modeling tools provide inherent support for modeling domain scenarios with multiple classification levels. However, as the success of domain-specific modeling tools illustrates users increasingly expect to be able to visualize models using domain-specific languages. It is relatively straightforward to support this using traditional “two-level” modeling technologies, but many of the ...

The idea of the Neurath Basic Model View Controller (NBMVC) appeared during the discussion of the design of domain-specific modelling tools based on the Neurath Modelling Language [1]. The NBMVC is the core of the modelling process within the modelling environment. It reduces complexity out of the design process by providing domain-specific interfaces between the developer and the model. These ...

OBJECTIVES To explore the attitudes of men with confirmed or suspected prostate cancer to testing for prostate specific antigen. DESIGN Qualitative interview study with a purposive sample. SETTING Great Britain. PARTICIPANTS 52 men with suspected or confirmed prostate cancer, recruited through general practitioners, urologists, patient support groups, and charities. RESULTS Almost all m...

The conformation of ten purified tRNAs from Escherichia Coli has been investigated by means of the photo-induced cross-linking of 4Srd8 and Cyd13, which is sensitive to the juxtaposition of the two bases. Three tRNAs photo-react abnormally slowly; tRNAPhe, tRNAMet/m a and tRNAVal/2; a comparison with normally reacting species suggests that base 47 (Urd or modified Urd) is involved in a tertiary...

BACKGROUND Prostate-specific antigen (PSA) assays have historically produced different results. Our aim was to investigate the comparability of assay results of selected commercially available assay methods designed to measure total, free, or complexed PSA (tPSA, fPSA, and cPSA). METHODS We measured tPSA, fPSA, and cPSA in 70 samples and in the WHO PSA 96/670 reference preparation with 6 assa...

Phylogenetic relationships among frogs of the genus Rana from western North America are investigated using 2013 aligned bases of mitochondrial DNA sequence from the genes encoding ND1 (subunit one of NADH dehydrogenase), tRNAIle, tRNAGln, tRNAMet, ND2, tRNATrp, tRNAAla, tRNAAsn, tRNACys, tRNATyr, and COI (subunit I of cytochrome c oxidase), plus the origin for light-strand replication (OL) betw...

A variety of factors is making it increasingly difficult and expensive to design and manufacture traditional Application Specific Integrated Circuits (ASICs). This has started a significant move towards the use of programmable solutions of various forms – increasingly referred to as programmable platforms. For the platform manufacturer, programmability provides higher volume to amortize design ...