Central serotonin (5-HT) dysregulation contributes to the susceptibility for mental disorders, including depression, anxiety, and posttraumatic stress disorder, and learning and memory deficits. We report that the formation of hippocampus-dependent spatial memory is compromised, but the acquisition and retrieval of contextual fear memory are enhanced, in central 5-HT-deficient mice. Genetic del...

This paper aims to study the representational nature of human object-location memory. Two experiments are reported, including both performance data and eye movement data. The results show that multiple allocentric frames of reference are used to encode spatial relationships among objects and late computation in object-location memory retrieval in objectcued conditions is often inevitable. The i...

Nonreinforced retrieval can cause extinction and/or reconsolidation, two processes that affect subsequent retrieval in opposite ways. Using the Morris water maze task we show that, in the rat, repeated nonreinforced expression of spatial memory causes extinction, which is unaffected by inhibition of protein synthesis within the CA1 region of the dorsal hippocampus. However, if the number of non...

objective(s) cyclooxygenases  (coxs) are known to play some roles in physiological mechanisms related to learning and memory. since sodium salicylate is an inhibitor of cox, we have evaluated the effect of peripheral and intra-hippocampal administration of sodium salicylate on spatial learning and memory in male rats. materials and methods male rats were studied in two groups; the first group r...

Previous studies have indicated that stress-activated glucocorticoid hormones induce temporary memory retrieval impairment. The present study examined whether adrenal steroid receptors in the hippocampus mediate such glucocorticoid effects on spatial memory retrieval. The specific glucocorticoid receptor (GR) agonist 11beta, 17beta-dihydroxy-6,21-dimethyl-17alpha-pregna-4,6-trien-20yn-3-one (RU...

This paper presents a model of memory for multidimensional stimuli. The model captures the independence of features in memory, their recovery using spatial location and temporal cues, and the role of verbal recoding in building integrative feature memories. The model fits data showing that object features may be retrieved independently when given a location cue, but that correct retrieval of mi...

Co-speech gestures traditionally have been considered communicative, but they may also serve other functions. For example, hand-arm movements seem to facilitate both spatial working memory and speech production. It has been proposed that gestures facilitate speech indirectly by sustaining spatial representations in working memory. Alternatively, gestures may affect speech production directly by...