We have determined the protein X-ray crystal structures of four organometallic inhibitors in complex with their target enzyme carbonic anhydrase II. The barrel-shaped hydrophobic ferrocene and ruthenocene moieties have provided a structure-based avenue to better occupy the hydrophobic binding patch within the enzyme active site.

When purified without the use of ionic detergents, both OmpA and OprF proteins contained nearly 20% alpha-helical structures, which disappeared completely upon the addition of sodium dodecyl sulfate. This result suggests that the proteins fold in a similar manner, with an N-terminal, membrane-spanning beta-barrel domain and a C-terminal, globular, periplasmic domain.

As Talmy has observed, language schematizes space; language provides a systematic framework to describe space, by selecting certain aspects of a referent scene while neglecting the others. Here, we consider the ways that space and the things in it are schematized in perception and cognition, as well as in language. We propose the Schematization Similarity Conjecture: to the extent that space is...

A non-Hermitian complex symmetric 2 × 2-matrix toy model is used to study projective Hilbert space structures in the vicinity of exceptional points (EPs). The bi-orthogonal eigenvectors of a diagonalizable matrix are Puiseuxexpanded in terms of the root vectors at the EP. It is shown that the apparent contradiction between the two incompatible normalization conditions with finite and singular b...

In this work we place some of the traditional biometrics work on fingerprint verification via the fuzzy vault scheme within a cryptographic framework. We show that the breaking of a fuzzy vault leads to decoding of Reed-Solomon codes from random errors, which has been proposed as a hard problem in the cryptography community. We provide a security parameter for the fuzzy vault in terms of the de...

previous studies have shown that the receptive field properties, spontaneous activity and spatio-temporal interactions of low-threshold mechanical somatosensory cells in the barrel cortex are influenced by c-fibers. in this study, we examined the effect of c-fiber depletion on response properties of barrel cortex neurons following experience dependent plasticity. methods: in this study, exterac...