Sclerosing Polycystic Adenosis (SPA) is a rare disease of the salivary glands, first described by Smith et al. in 1996, with histomorphological aspects similar to those from breast fibrocystic disorders1. Its pathogenesis is still unclear; however, it is considered a pseudo-neoplastic or reactive process. Recently, Skálová et al. showed clonality in six SPA cases. SPA affects mainly the parotid...

Targeted positioning of water channel aquaporin-2 (AQP2) strictly regulates body water homeostasis. Trafficking of AQP2 to the apical membrane is critical to the reabsorption of water in renal collecting ducts. Controlled apical positioning of AQP2 suggests the existence of proteins that interact with AQP2. A biochemical search for AQP2-interacting proteins led to the identification of PDZ-doma...

In the previous paper(Ito et al., 1965), it was described that the oral administration of saliva-parotin-A(abbr. as SPA) caused various biological responses such as the hypocalcemia in rabbits, the promotion of calcification in rabbit incisor dentine and the excretion of potent uro-parotin in sialoadenectomized rabbits. Those responses are recognized as the biological properties of parotin and ...

INTRODUCTION Superficial palmar arch (SPA) is dominant vascular structure in palm of hand. In present study we described a case of Ulnar / Radiopalmar pattern of incomplete SPA in an Iranian cadaver. When the SPA is complete, the superficial palmer branches of the radial artery contribute to the ulnar artery. In incomplete type of SPA, there was no anastomosis between the ulnar and radial arter...

Address for Correspondence: Dr.(Mrs) Subhra Mandal, MD (Anatomy), Associate Professor, Medical College Kolkata, West Bengal, India. Mobile no.:+919477458100 E-Mail: [email protected] The functional importance of hand is revealed by its rich vascularity contributed by superficial and deep palmar arches (SPA and DPA).Superficial palmar arch is located superficial to flexor tendons, and deep...

BACKGROUND/AIMS Osteomyelitis is a debilitating infectious disease of the bone which is predominantly caused by Staphylococcus aureus (S. aureus). The purpose of this study was to investigate the role of the S. aureus virulence factors, i.e. protein A (SpA), Panton-Valentine leukocidin (PVL) and coagulase (Coa) on osteomyelitis. METHODS The effect of SpA, PVL and Coa on osteoblasts was studie...

Background: Crohn’s disease is associated with an increased number of macrophages in ileal and colonic mucosa. Data on macrophages in gut mucosa of patients with spondyloarthritis (SpA) are scarce. Objective: To investigate macrophages and other antigen presenting cells in gut mucosa from patients with SpA and Crohn’s disease, given the relationship between both entities. Methods: Biopsy specim...

Background This study sought to understand the epidemio-ecological dynamics of MRSA isolates associated with a South African hospital over a period spanning year 2007-8 (a previous study reported in 2009) and year 2010-11 (this study). Methods One hundred and ninety three isolates were characterised by molecular fingerprinting methods including pulsed field gel electrophoresis (PFGE), spa typ...

OBJECTIVE To assess the willingness to pay (WTP) for treatment in a spa resort of patients with ankylosing spondylitis (AS) and to assess if the experience of a spa influences the WTP. METHODS 120 patients participating in a randomised trial comparing 3 weeks' treatment in a spa resort in Austria or in the Netherlands with a control group completed a WTP questionnaire before and after spa tre...

The binding specificity of rheumatoid factors (RFs) to human Fc resembles that of some microbial Fc-binding proteins, suggesting conformational similarities in their Fc-binding regions. Using polyclonal chicken antibodies against SPA, we have detected a crossreactive determinant shared by human RFs from different individuals, but not by non-RF IgM and IgG. Chicken anti-SPA was shown to bind to ...