objective (s):hyperglycemia is widely recognized as the underlying cause for some debilitating conditions in diabetic patients. the role of cannabinoid cb1 and vanilloid trpv1 receptors and their endogenous agonists, endovanilloids, in diabetic neuropathy is shown in many studies. here we have used pc12 cell line to investigate the possible influence of glucose concentration in culture medium o...

introduction dendritic cells (dcs) are bone marrow-derived cells, which migrate to lymphoid and non-lymphoid organs via blood. liver dcs are believed to play an important role in the regulation of hepatic allograft acceptance. however, because of inherent difficulties in isolating adequate numbers of dcs from liver, limited information is available on the phenotype and functions of liver dcs. t...

how to cite this article: amirsalary s, dehghan l, dalvand h, haghgoo h. effectiveness of neurogenesis in treating children with cerebral palsy. iran j child neurol 2012;6(2):1-8.   objective tissue-specific stem cells divide to generate different cell types for the purpose oftissue repair in the adult. the aim of this study was to detect the significance ofneurogenesis in the central nervous s...

background: after improvements in various cancer treatments, life expectancy has been raised, but success in treatment causes loss of fertility in many of the survived young men. cryopreservation of immature testicular tissues or cells introduced as the only way to preserve fertility. however, freezing has some harmful effects. melatonin, a pineal gland hormone, has receptors in reproductive sy...

background and objectives: significant progress has been made in treatment of hemophilia. ex-vivo gene therapy is going popular due to the capability of this method in using isogenic cells for genetic manipulation and reintroducing them into same host after proliferation. most gene therapy techniques use viral vectors, which usually harbor a strong and non-specific promoter (e.g. cmv early prom...

testosterone is believed to play a significant role in spermatogenesis, but its contribution to the process of spermatogenesis is not completely understood. given that extracellular matrix (ecm) facilitates differentiation of spermatogonial stem cells (sscs) during culture, the present study was conducted to elucidate whether testosterone contribute to the permissive effect of ecm on sscs diffe...

luteolin is a flavone in medicinal plants as well as some vegetables and spices. it is a natural anti-oxidant with less pro-oxidant potential but apparently with a better safety profile. the purpose of this study was to investigate the molecular mechanism of luteolin-mediated apoptosis of mg-63 human osteosarcoma cells. mtt assay kit was employed to evaluate the effects of luteolin on mg-63 cel...

it has been reported that several conifers possess cytotoxic activities on some human tumor cell lines. taxol as a natural cytotoxic compound has been extracted from this family. in a program to screen the cytotoxic effects of natural resources, male and female branchlets, fruit or bark of two different species of iranian conifers were collected, identified and the cytotoxic effects of their hy...

background: arsenic is one of the most toxic metalloids. anemia and leukopenia are common results of poisoning with arsenic, which may happen due to a direct hemolytic or cytotoxic effect on blood cells. the aim of this study was to examine the effects of hydroalcoholic extract of nasturtium officinale on blood cells and antioxidant enzymes in rats exposed to sodium (meta)arsenite. methods: 32 ...

background: essential oils are found to have multiple active components which can show in vitro cytotoxic action against various cancerous cell lines. this study reports the in vitro cytotoxic effects of the essential oil from artemisia absinthium l. (asteraceae) growing wild in iran. methods: water-distilled essential oil of a. absinthium collected from ardabil, north-western iran, was examine...