Structural transformations of vesicles to micelles that take place during the interaction of sodium dodecyl sulfate (SOS) with individual and mixed vesicles of phosphatidyl choline (PC) and phosphatidic acid (FA), have been studied by monitoring changes in optical density and in the concentration of free SOS monomer in the respective systems. Incorporation of the surfactant monomers (SOS) in th...

The classical model for the activation of the nucleotide exchange factor Son of sevenless (SOS) involves its recruitment to the membrane, where it engages Ras. The recent discovery that Ras*GTP is an allosteric activator of SOS indicated that the regulation of SOS is more complex than originally envisaged. We now present crystallographic and biochemical analyses of a construct of SOS that conta...

While recent advances in computing/communications technology have enabled the development and managed evolution of large scale system of systems (SoS) applications, lessons learned from industry indicate that these projects are not always successful. A key problem is the lack of a formal framework from which the development and management of SoS architectures can be studied. This paper describe...

Regulated activation of Ras by receptor tyrosine kinases (RTK) constitutes a key transduction step in signaling processes that control an array of fundamental cellular functions including proliferation, differentiation, and survival. The principle mechanism by which Ras is activated down stream of RTKs involves the stimulation of guanine nucleotide exchange by the ubiquitous guanine nucleotide ...

Sinusoidal obstruction syndrome (SOS)/hepatic veno-occlusive disease (VOD) is a fatal complication after hematopoietic stem cell transplantation. We previously reported the usefulness of an ultrasonographical (US) scoring system, Hokkaido US-based system consisting ten parameters (HokUS-10): (1) hepatomegaly in left lobe and (2) right lobe, (3) dilatation main portal vein (PV), (4) hepatofugal ...

Post-transcriptional regulation of gene expression plays a crucial role in many bacterial pathways. In particular, the translation of mRNA can be regulated by trans-acting, small, non-coding RNAs (sRNAs) or mRNA-binding proteins, each of which has been successfully treated theoretically using two-component models. An important system that includes a combination of these modes of post-transcript...

in today’s advanced world resulting from the improvement of technology, societies tend to encounter a large number of problems and accidents. as we know, university’s security personnel are classified as shift workers and are exposed to health disturbing factors. the aim of this study was investigation of shift work disorders among security personnel of the hospitals affiliated to shiraz univer...

Bacterial infections can be aggravated by antibiotic treatment that induces SOS response and vesiculation. This leads to a hypothesis concerning association of SOS with vesiculation. To test it, we conducted multiple analyses of outer membrane vesicles (OMVs) produced from the Pseudomonas aeruginosa wild type in which SOS is induced by ciprofloxacin and from the LexA noncleavable (lexAN) strain...

Modern systems are becoming increasingly complex, integrated and distributed, in order to meet the escalating demands for functionality. This has given rise to concepts such as system-of-systems (SoS), which organise a myriad of independent component systems into a collaborative super-system, capable of achieving unmatchable levels of functionality. Despite its advantages, SoS is still an infan...

Our economy and national well-being is highly dependent on Critical Infrastructures (CIs). Today, CIs rely heavily on ICT and are often embedded within systems of systems. This makes CIs particularly vulnerable to security threats. In this paper we address the methodological challenge of how to estimate the impact that interdependencies within a System of Systems (SoS) have on the overall secur...