نتایج جستجو برای: somatic chromosome
تعداد نتایج: 159086 فیلتر نتایج به سال:
RECOMBINATION in somatic cells of Drosophila is influenced by various genetic and environmental factors that also affect meiotic recombination. Thus, the amount of somatic crossing over in a given chromosome is controlled by the genetic contents of the chromosomal set (WEAVER 1960) and by the presence of various genes (STERN 1936; KAPLAN 1953). It may also be affected by changes in temperature ...
Ataxia telangiectasia (AT) is a chromosome instability (CIN) neurological syndrome arising from DNA damage response defects due to ATM gene mutations. The hallmark of AT is progressive cerebellar degeneration. However, the intrinsic cause of the neurodegeneration remains poorly understood. To highlight the relationship between CIN and neurodegeneration in AT, we monitored aneuploidy and interph...
Previous studies using somatic cell hybridization of highly metastatic and nonmetastatic rat prostatic cancer cells demonstrated that the resultant hybrids were nonmetastatic if all of the parental chromosomes were retained. Somatic hybrid segregants which underwent nonrandom chromosomal losses reexpressed high metastatic ability. These results demonstrated that there are gene(s) the expression...
Chromophobe renal cell carcinoma (chRCC) typically shows ~7 chromosome losses (1, 2, 6, 10, 13, 17, and 21) and ~31 exonic somatic mutations, yet carries ~5%-10% metastatic incidence. Since extensive chromosomal losses can generate proteotoxic stress and compromise cellular proliferation, it is intriguing how chRCC, a tumor with extensive chromosome losses and a low number of somatic mutations,...
In female mammalian cells, one of the two X chromosomes is inactivated to compensate for gene-dose effects, which would be otherwise doubled compared with that in male cells. In somatic lineages in mice, the inactive X chromosome can be of either paternal or maternal origin, whereas the paternal X chromosome is specifically inactivated in placental tissue. In human somatic cells, X inactivation...
Fluorescence in situ hybridization analysis, performed with chromosome specific DNA probes labeled with fluorochromes, is a simple and reliable tool for the indirect study of aneuploidies in interphase cells such as spermatozoa. It is known that infertile male patients with poor sperm quality, due to different causes, produce cytogenetically abnormal spermatozoa despite a normal constitutional ...
Because of its importance in sugarcane breeding as a source high productivity and adaptability, efforts made to collect, conserve characterize Saccharum spontaneum accessions from different parts the country. Chromosomal diversity correlation with characters recorded during collection this species have been revealed through study 71 clones collected Jharkhand, state located eastern India. A tot...
شمارش کروموزومی و تجزیه کاریوتیپ تعداد پنج مانگرو تک‌لپه از در دارما و ساحل پارادیپ در اوریسا (هندوستان) نشان داد که در گونه 48=n2 Porteresia coarctata ، در گونه‌های Crinum defixum و 22=n2 Cryptocaryne ciliata ، در گونه‌های Asparagus racemosus var. javanica و Cyperus cephalotes 20=n2 می‌باشد. طول کل کروموزومی از 44/42 در گونه Asparagus racemosus var. javanica تا 86/93 در گونه Crinum defixum ...
Abnormalities of chromosome 17 are important molecular genetic events in human breast cancers. Several famous oncogenes (HER2, TOP2A and TAU), tumor suppressor genes (p53, BRCA1 and HIC-1) or DNA double-strand break repair gene (RDM1) are located on chromosome 17. We searched the literature on HER2, TOP2A, TAU, RDM1, p53, BRCA1 and HIC-1 on the Pubmed database. The association of genes with chr...
Somatic cell hybrids between mouse and human corneal stroma fibroblasts have been used to identify the human chromosome responsible for the synthesis of human corneal type I procollagen. Twenty-six separate hybrid clones and subclones from three separate hybridization events were isolated in hypoxanthine-aminopterin-thymidine (HAT) selection medium and were used to assay for the production of h...
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