Objective(s):Solid dispersion formulation is the most promising strategy to improve oral bioavailability of poorly water soluble drugs. The aim of this study was to compare the effect of polyvinylpyrrolidone K30 (PVP) and poloxamer-188 (PLX) as carrier in solid dispersion formulations of celecoxib (CLX). Materials and Methods: Solid dispersions of CLX:PVP or CLX:PLX were prepared at different r...

This article engages with critiques of multilevel governance (MLG) perspectives on asylum and identifies two additional points concern. First, it highlights the importance empirically grounding reflections limits MLG approach, beyond activism city actors, by examining local dynamics from vantage point mayors in rural small urban municipalities. It examines how Dutch municipalities province Zeel...

This paper presents a numerical investigation for laminar forced convection flow of a radiating gas in a rectangular duct with a solid element that makes a backward facing step. The fluid is treated as a gray, absorbing, emitting and scattering medium. The governing differential equations consisting the continuity, momentum and energy are solved numerically by the computational fluid dynamics t...

The paper reports an investigation into the forging of solid powder circular disc with large slenderness ratio, between two flat dies. The deformation pattern during the operation is influenced by many factors, which interact with each other in a complex manner. The decisive factors are the interfacial conditions, initial relative density of the preform and the geometry of the preform. An attem...

−Dilute acid pretreatment of lignocellulosic material is one of the significant steps in a biorefinery. We used response surface methodology to determine the important factors of formic acid concentration (2%-6% wt%), treatment time (30-150 min), reaction temperature (120-160 oC), and liquid to solid ratio (3-11 mL/g) on dilute acid hydrolysis of corn cob to produce xylose. A xylose yield of 81...

Article history: Received on: 09/03/2013 Accepted on: 07/05/2013 Available online: 30/05/2013 Paris fargesii is a famous Chinese traditional medicinal plant used as antipyretic, antidotal, antiphlogistic and analgesic. This research aimed at the determination of the total polysaccharides contents in P. fargesii, which were collected from Baoxing country of Sichuan Province in order to get the o...

The Brönsted acidic ionic-liquid [HO(3)S(CH(2))(4)mim] HSO(4), a novel dual catalyst-solvent, has been successfully applied in simultaneous microwave-assisted extraction and hydrolysis for the determination of flavonol glycosides in Ginkgo foliage. The parameters, namely the [HO(3)S(CH(2))(4)mim]HSO(4) concentration, microwave-irradiation power, microwave-irradiation time, and solid-liquid rati...

When countries are impacted by a crisis, comparisons at the national level often drawn. Whilst useful, this approach fails to explore how local measures enacted alongside centralised responses. This paper addresses that gap examining England’s intergovernmental response Covid-19 pandemic. With focus on multi-level governance (MLG) and resilience theories explores tiers of government respond dem...