the aggregation of protein is the most prevalent and the most disturbing kind of instability and this challenge exists in almost every stage of the development of protein drug. the presence of insoluble aggregations in protein drugs will make the supply of the product a tough job. this study identifies the inhibition of the folded interferon beta 1-b’s aggregation with the assistance of some ex...

epidemiologic studies show that the cardiovascular diseases are associated with multiple factors such as raised serum total cholesterol, increased ldl, increased platelet aggregation, hypertension and smoking. in-vitro studies have confirmed the ability of some plants of allium species to reduce these parameters. therefore, we evaluated anti-platelet aggregation effect of some allium species (a...

Identifying nanomaterial-bio-interactions are imperative due to the broad introduction of nanoparticle (NP) applications and their distribution. Here, we demonstrate that silica NPs effect widespread protein aggregation in the soil nematode Caenorhabditis elegans ranging from induction of amyloid in nucleoli of intestinal cells to facilitation of protein aggregation in body wall muscles and axo...

When grown under suboptimal conditions, rhizobacteria of the genus Azospirillum produce high levels of poly-beta-hydroxybutyrate (PHB). Azospirillum brasilense strain Sp7 and a phbC (PHB synthase) mutant strain in which PHB production is impaired were evaluated for metabolic versatility, for the ability to endure various stress conditions, for survival in soil inoculants, and for the potential ...

Accurate knowledge of water fluxes in the vadose zone of watersheds is important for applications such as water resources management and climate forecasting. Most, if not all, large-scale studies follow a pragmatic approach where simplifying assumptions have to be made regarding problem formulation and estimation of hydraulic properties. This study investigates simplifications in both regards t...

Ants are ubiquitous members of most forest communities, where they disperse seeds, prey on other species, and influence the flow of nutrients. Their effects are often described as substantial, but few studies to date have simultaneously examined how the presence of ants affects both above and belowground processes. In this study, we experimentally reduced ant abundance in a suite of deciduous f...

background and objective: nitric oxide (no) plays a role in thermoregulation and growth of protozoa. this work aimed to add the molecule no in physiology of protozoa in contact with abused narcotic substances. materials and methods: a sedative drug, morphine, was infused into a cell chamber containing paramecia . the cell response to the drug was recorded promptly after drug infusion using a po...

energy consumption is considered as a critical issue in wireless sensor networks (wsns). batteries of sensor nodes have limited power supply which in turn limits services and applications that can be supported by them. an efcient solution to improve energy consumption and even trafc in wsns is data aggregation (da) that can reduce the number of transmissions. two main challenges for da are: (i)...

background since genetic and most environmental factors shape the context of families, some studies have been initiated to investigate the role of familial relationships in metabolic syndrome (mets). objectives to estimate the familial aggregation of mets and its components by identifying both case and control probands among tehranian adults with different socio-behavioral and reproductive char...