Blood vessels express 3 isoforms of superoxide dismutase (SOD): cytosolic or copper-zinc SOD (CuZn-SOD), manganese SOD (Mn-SOD) localized in mitochondria, and an extracellular form of CuZn-SOD (EC-SOD). Because there are no selective pharmacological inhibitors of individual SOD isoforms, the functional importance of the different SODs has been difficult to define. Recent molecular approaches, p...

Superoxide dismutase (SOD) fusion of TAT was proved to be radioprotective in our previous work. On that basis, a bifunctional recombinant protein which was the fusion of glutathione S-transferase (GST), SOD, and TAT was constructed and named GST-TAT-SOD. Herein we report the investigation of the cytotoxicity, cell-penetrating activity, and in vitro radioprotective effect of GST-TAT-SOD compared...

When cultured anaerobically in a chemically defined medium that was treated with Chelex-100 to lower its trace metal content, Streptococcus mutans OMZ176 had no apparent requirement for manganese or iron. Manganese or iron was necessary for aerobic cultivation in deep static cultures. During continuous aerobic cultivation in a stirred chemostat, iron did not support the growth rate achieved wit...

The purpose of the present study was to investigate the effects of swimming training on the changes in three superoxide dismutase (SOD) isoenzymes in mice. The trained mice underwent a 6-wk swimming program (1 h/day, 5 days/wk) in water at 35-36 degrees C. Immunoreactive extracellular SOD (EC-SOD), copper- and zinc-containing SOD (CuZn-SOD), and manganese-containing SOD (Mn-SOD) contents and th...

OBJECTIVE To investigate the status and contribution of oxidized superoxide dismutase (SOD) in systemic lupus erythematosus (SLE), and to explore whether oxidized-SOD has a role in disease induction and progression. METHODS This study was performed in the College of Medicine, Qassim University, Buraidah, Kingdom of Saudi Arabia between October 2011 and May 2012. The study was designed to expl...

Background Oleanolic acid (OA) has notable anti-inflammatory and anti-tumor effects, but the role of OA in cerebral ischemia-reperfusion injury (CIRI) not been reported so far. Methods Oxygen glucose deprivation/reoxygenation (OGD/R) model was induced PC12 cells. MTT assay used to detect cell viability cells, while ELISA detected expression TNF-?, IL-1? IL-6. The superoxide dismutase (SOD), mal...

Purpose: To explore the influence of lncRNA FOXD3-AS1 on high glucose (HG)-stimulated human lens epithelial cell injury in diabetic cataract. Methods: Lens HLEB3 were cultured vitro and transfected with si-FOXD3-AS1, miR-338-3p mimic or inhibitor, followed by HG (40 mmol/L) treatment. FOXD3-AS1, miR-338-3p, cleaved caspases3 caspases9 expression analyzed RT-qPCR western blot. SOD CAT activities...

Niacin may cause evaporative thermolysis through cutaneous hyperemia, vasodilation, increased sweating rate and decreased skin temperature. It is antilipolytic can improve metabolic responses. Heat stress ameliorative effects of rumen protected niacin (RPN) supplementation in lactating Surti buffaloes during summer has been investigated present study. Fourteen were divided into two groups (Cont...

Karrikins are active components of smoke that can promote seed germination and regulate seedling morphogenesis. However, the role karrikins as alleviators abiotic stress remains largely elusive. In this study, we examined whether exogenous application karrikin1 (KAR1) might improve drought tolerance in creeping bentgrass (Agrostis stolonifera cv. PennA4), investigated underlying mechanism. We f...

The superoxide dismutases (SODs), which catalyze the dismutation of 2 superoxide anions to hydrogen peroxide and oxygen, represent major antioxidant mechanisms in single-cell organisms, plants, bacteria and eukaryotes. In mammalian cells, there are 3 forms of SOD that include the mitochondrial manganese SOD (MnSOD or SOD2), the cytoplasmic SOD that is a copper/zinc-containing enzyme (Cu/Zn SOD ...