نتایج جستجو برای: smooth muscle contraction

تعداد نتایج: 417858  

Journal: :The Japanese journal of veterinary research 1994
K Kubota S Ito T Ohta Y Nakazato A Ohga

The purpose of the present experiments was to examine the mechanism of the proventricular dilatation caused by lead in the isolated vagus nerve-proventricular smooth muscle preparation of the chick. Lead caused dose- and time-dependent inhibition of contractions induced by vagal stimulation, transmural stimulation and externally applied acetylcholine (ACh). Vagally evoked contraction was much m...

2017
Eileen Miller Alicja Czopek Karolina M. Duthie Nicholas S. Kirkby Elisabeth E. Fransen van de Putte Sibylle Christen Robert A. Kimmitt Rebecca Moorhouse Raphael F.P. Castellan Yuri V. Kotelevtsev Rhoda E. Kuc Anthony P. Davenport Neeraj Dhaun David J. Webb Patrick W.F. Hadoke

The role of smooth muscle endothelinB (ETB) receptors in regulating vascular function, blood pressure (BP), and neointimal remodeling has not been established. Selective knockout mice were generated to address the hypothesis that loss of smooth muscle ETB receptors would reduce BP, alter vascular contractility, and inhibit neointimal remodeling. ETB receptors were selectively deleted from smoot...

Journal: :Circulation research 1973
D F Bohr

• This brief review of the rapidly developing research on vascular smooth muscle presents the state of the art as I see it from within my own frame of reference. For a more objective, detailed insight into the workings of vascular smooth muscle, several substantial reviews and compendiums may be read (1-7). The mechanical events responsible for the contraction of vascular smooth muscle are asso...

2017
Zhili Xu Mingbo Zhang Deqiang Dou Xiaojun Tao Tingguo Kang

BACKGROUND Berberine is a natural isoquinoline alkaloid possessing various pharmacological effects, particularly apparent in the treatment of diarrhea, but the underlying mechanism remains unclear. Smooth muscle myosin light-chain kinase (MLCK) plays a crucial role in the smooth muscle relaxation-contraction events, and it is well known that berberine can effectively depress the contraction of ...

Journal: :Gastroenterology 2009
Volodymyr V Tsvilovskyy Alexander V Zholos Thomas Aberle Stephan E Philipp Alexander Dietrich Michael X Zhu Lutz Birnbaumer Marc Freichel Veit Flockerzi

BACKGROUND & AIMS Downstream effects of muscarinic receptor stimulation in intestinal smooth muscle include contraction and intestinal transit. We thought to determine whether classic transient receptor potential (TRPC) channels integrate the intracellular signaling cascades evoked by the stimulated receptors and thereby contribute to the control of the membrane potential, Ca-influx, and cell r...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2005
Sita Somara Haiyan Pang Khalil N Bitar

Smooth muscle contraction regulated by myosin light chain phosphorylation is also regulated at the thin-filament level. Tropomyosin, a thin-filament regulatory protein, regulates contraction by modulating actin-myosin interactions. Present investigation shows that acetylcholine induces PKC-mediated and calcium-dependent phosphorylation of tropomyosin in colonic smooth muscle cells. Our data als...

Journal: :Clinical and experimental pharmacology & physiology 2006
Shigeru Hishinuma Masaki Saito

1. To explore roles of intracellular Ca(2+) stores in excitation-contraction coupling in smooth muscle, we examined the effects of ryanodine, a fixer of ryanodine receptor-Ca(2+) channels to an open state, and thapsigargin, a selective inhibitor of the Ca(2+) pump in the intracellular stores, on smooth muscle contraction in the presence and absence of extracellular Ca(2+) in guinea-pig taenia c...

Journal: :The Journal of pharmacology and experimental therapeutics 1983
A R Leff N M Munoz S G Hendrix

The response of canine tracheal and bronchial smooth muscle to i.a. administered agonists causing smooth muscle contraction was compared in 22 mongrel dogs in vivo. Tracheal and bronchial contractile responses were measured isometrically in situ in the same dogs. In nine dogs, dose-response curves were generated with i.a. acetylcholine and histamine (10(-10) to 10(-6) mol) in a 4-cm tracheal se...

2013
Sun-Ouck Kim Seung Hee Song Seung-Chul Lee Kyung Aa Cho Jong Sung Park Dongdeuk Kwon Kwangsung Park

BACKGROUND The purpose of this study was to investigate the effect of estrogen alteration on the expression of caveolin 2 and 3 in rat smooth muscle of urinary bladder. METHODS Female Sprague-Dawley rats were divided into three groups: control, bilateral ovariectomy (Ovx), and bilateral ovariectomy followed by subcutaneous injections of 17β-estradiol (Ovx+Est). After 4 weeks, urodynamic measu...

Journal: :Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 2004
Toshimitsu Uchiyama Russell Chess-Williams

The parasympathetic nervous system is responsible for maintaining normal intestinal and bladder function, contracting the smooth muscle by releasing the neurotransmitters acetylcholine (ACh) and ATP and relaxing sphincters by releasing nitric oxide. ACh is the main transmitter released and smooth muscle contraction is mediated via a mixed M2/M3 receptor population; M3 receptors acting via phosp...

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