Sphingomyelin (SM) synthase has been assumed to be involved in both cell death and survival by regulating pro-apoptotic mediator ceramide and pro-survival mediator diacylglycerol. However, its precise functions are ambiguous due to the lack of molecular cloning of SM synthase gene(s). We isolated WR19L/Fas-SM(-) mouse lymphoid cells, which show a defect of SM at the plasma membrane due to the l...

a r t i c l e i n f o Keywords: 146 Sm– 142 Nd systematics eucrites early planetary differentiation isotope distribution through solar system Short-lived 146 Sm– 142 Nd and long-lived 147 Sm– 143 Nd chronometers have been measured in three cumulate eucrites (Binda, Moore County and Moama). The two major mineral phases (plagioclase and pyroxene) present in these achondrites are characterized by ...

Elucidation of the molecular mechanisms governing the osteogenic differentiation of human mesenchymal stem cells (hMSCs) is of great importance for improving the treatment of bone-related diseases. MicroRNAs (miRNAs or miRs), a class of small non-coding RNAs, are critical in a number of biological processes, including the proliferation, differentiation and survival of cells and organisms. Emerg...

Introduction: The target-organ approach of AFAST SM and the AFAST SM -applied fluid scoring system, the FAST DH view, and the TFAST SM format that also assesses heart and lung, encourages the sonographer using these abbreviated formats to look beyond the simplified objective of fluid-positive or fluid-negative FAST approaches. The Global FAST SM approach using these 3 techniques (AFAST SM , TFA...

Polychlorinated biphenyls (PCB) is a major type of persistent organic pollutants (POPs) that act as endocrine-disrupting chemicals. In the current study, we examined the mechanism underlying the effect of PCB-153 on glucose and lipid metabolism in vivo and in vitro. We found that PCB-153 induced per se and worsened high fat diet (HFD)-resulted increase of blood glucose level and glucose and ins...

A three-dimensional/high-resolution transport model for persistent organic pollutants (POPs) has been developed for the East China Sea (ECS). The POPs model has four compartments (gaseous, dissolved, phytoplankton-bound, and detritus-bound phases) and includes processes for diffusive air-water exchange, phytoplankton uptake/depuration to POPs, decomposition of dissolved phase, vertical sinking ...