BACKGROUND Polymorphic variants within human melanocortin-3 receptor gene (MC3R) gene have been associated with obesity. However, its influence on infancy and early childhood adiposity has not been reported before. OBJECTIVES We assessed associations between genotype at polymorphic sites within MC3R with early childhood adiposity and interaction with early childhood appetitive traits. METHO...

The primary manifestations of Parkinson's disease are abnormalities of movement, including movement slowness, difficulties with gait and balance, and tremor. We know a considerable amount about the abnormalities of neuronal and muscle activity that correlate with these symptoms. Motor symptoms can also be described in terms of motor control, a level of description that explains how movement var...

The aim of this document is to summarise the information on elastic material properties, and wave propagation which I have found in my recent reading. The books and papers read are listed at the end of this document, and cited throughout. First, the basic consititutive equations governing elastic solids are presented. Once the concept of elastic properties has been established, our attention tu...

Adjoint-state methods (ASMs) have proven successful for calculating the gradients of the functionals commonly found in geophysical inverse problems. The 3D ASM imagedomain tomography (IDT) formulation of the seismic velocity estimation problem highlights imperfections in migrated image volumes and, using appropriate penalty functions (e.g., differential semblance), forms an objective function t...

Parkinson's disease (PD) is the most common movement disorder encountered in movement disorder clinics but psychogenic parkinsonism (PP) is relatively rare. Based on a study of 32 patients, coupled with a comprehensive review of the literature, the diagnosis, clinical phenomenology, epidemiology, natural history, imaging and treatment, this article provides a critical review of PP. In addition ...

BACKGROUND AND PURPOSE The sequence effect (SE) in Parkinson's disease (PD) denotes progressive slowness in speed or progressive decrease in amplitude of repetitive movements. It is a well-known feature of bradykinesia and is considered unique in PD. Until now, it was well-documented in advanced PD, but not in drug-naïve PD. The aim of this study is to know whether the SE can also be measured i...

In this paper, we analyze the performance of consensus protocols based on the rotating coordinator paradigm. We consider a simulated production environment, on which processing and communication resources available for the different processes running the protocols are not necessarily the same. Firstly, we show that, in some scenarios, the performance of the consensus protocol is enhanced when t...

The purpose of the present study was to investigate whether overreached athletes show psychomotor slowness after a period of high load training. Fourteen well-trained cyclists (10 male, 4 female, mean age 25.3 [SD = 4.1] years, mean maximal oxygen consumption 65.5 [SD = 8.1] ml/kg.min) performed a maximal graded exercise test on a cycle ergometer, filled out two questionnaires and performed two...

To decouple qP and qSV sheets of the slowness surface of a transversely isotropic (TI) medium, a sequence of rational approximations to the solution of the dispersion relation of a TI medium is introduced. Originally conceived to allow isotropic P-wave processing schemes to be generalized to encompass the case of qP-waves in transverse isotropy, the sequence of approximations was found to be ap...

Much recent attention has been devoted to gradient descent algorithms where the steepest descent step size is replaced by a similar one from a previous iteration or gets updated only once every second step, thus forming a faster gradient descent method. For unconstrained convex quadratic optimization these methods can converge much faster than steepest descent. But the context of interest here ...