In the present study, tryptamine produced a slow hyperpolarization in a few neurons other than a slow depolarization in myenteric neurons of the isolated guinea-pig ileum. Neither the adrenergic neuron blocker, guanethidine nor the 5-hydroxytryptamine uptake inhibitor, zimelidine, which can inhibit the release of 5-hydroxytryptamine from enteric neurites induced by tryptamine (M. Takaki et al. ...

Heterogeneity of release probability p between vesicles in the readily releasable pool (RRP) is expected to strongly influence the kinetics of depression at synapses, but the underlying mechanism(s) are not well understood. To test whether differences in the intrinsic Ca2+ sensitivity of vesicle fusion might cause heterogeneity of p, we made presynaptic Ca2+-uncaging measurements at the calyx o...

Ca(2+)-dependent transmitter release occurs in a fast and in a slow phase, but the differential roles of Ca(2+) buffers and Ca(2+) sensors in shaping release kinetics are still controversial. Replacing extracellular Ca(2+) by Sr(2+) causes decreased fast release but enhanced slow release at many synapses. Here, we established presynaptic Sr(2+) uncaging and made quantitative Sr(2+)- and Ca(2+)-...

BACKGROUND During the past few decades, the occurrence of superficial fungal infections has rapidly increased. As the fungal infections take longer time to get cured, concepts such as designing drugs with extended persistence and controlled release have gained attention. In this context, nanotechnology has been identified as the latest technological revolution which has opened up new pathways f...

Ørtenblad, Niels, Gisela Sjøgaard, and Klavs Madsen. Impaired sarcoplasmic reticulum Ca release rate after fatiguing stimulation in rat skeletal muscle. J Appl Physiol 89: 210–217, 2000.—The purpose of the study was to characterize the sarcoplasmic reticulum (SR) function and contractile properties before and during recovery from fatigue in the rat extensor digitorum longus muscle. Fatiguing co...

Abstract Slow-release polycarboxylate superplasticizer was synthetic under room-temperature conditions, a free radical copolymerization reaction occurred the action of redox initiator, and optimal preparation process temperature effect were discussed in detail. The results show that best (EP-15) is: acid-to-ether ratio is 1.89, amount NaH 2 PO 2.27%, appropriate 15-25°C, suitable macromonomer E...

Zirconium phosphate is able to intercalate basic molecules and it an effective drug carrier that can be used project slow release for topical applications.