Growing science and medical technologies have produced a massive amount of knowledge on different scales biological systems. By processing various amounts data, these will increase the quality disease detection enhance usability health information The integration machine learning in computer-based diagnostic systems facilitates early diseases, enabling more productive treatments prolonged survi...

Classical computing has well-established formalisms forspecifying, refining, composing, proving, and otherwise reasoningabout computations. These formalisms have matured over the past70 years or so.Unconventional Computing includes the use novel kinds of sub-strates – from black holes and quantum effects, through to chem-icals, biomolecules, even slime moulds – to perfor...

The culmination of the morphogenesis of the cellular slime mould Dictyostelium discoideum involves complex cell movements which transform a mound of cells into a globule of spores on a slender stalk. We show that cyclic AMP signalling and differential adhesion, combined with cell differentiation and slime production, are sufficient to produce the morphogenetic cell movements which lead to culmi...

Interspecific cell cohesion among 4 species of cellular slime moulds, Dictyostelium discoideum, D. mucoroides, D. purpureum and Polysphondylium violaceum has been studied. Binary mixtures of aggregation-stage cells of the 4 species were shaken in suspension, one species of each pair being labelled with [3H]thymidine. Cell aggregates were sampled at intervals over 24 h and their composition exam...

The transition from unicellular to multicellular organisms is one of the mysteries of evolutionary biology. Individual cells must give up their rights to reproduction and reproduce instead as part of a whole. I review and model the macrocyst stage in slime mould (Dictyostelium) evolution to investigate why an organism might have something to gain from joining a collective reproduction strategy....

Under suitable conditions of substrate supply, cell suspensions of yeast Saccharomyces uvarum may display synchronized oscillations of glycolytic metabolism. Also in an unstirred suspension, spatial patterns can be induced by continuously feeding enzymically liberated glucose into the system. the absorption of NADH in the suspension was measured in an annular cuvette. The observed structures di...

Growth factors and their binding proteins are important proteins regulating mammalian cell proliferation and differentiation so there is considerable interest in producing them as recombinant proteins, especially in hosts that do not already produce a complex mixture of growth factors. Many growth factors require post-translational modifications making them unsuitable for production in Escheric...